ID   MUTS_BRUO2              Reviewed;         898 AA.
AC   A5VN83;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BOV_0142;
OS   Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=444178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25840 / 63/290 / NCTC 10512;
RX   PubMed=19436743; DOI=10.1371/journal.pone.0005519;
RA   Tsolis R.M., Seshadri R., Santos R.L., Sangari F.J., Lobo J.M.,
RA   de Jong M.F., Ren Q., Myers G., Brinkac L.M., Nelson W.C., Deboy R.T.,
RA   Angiuoli S., Khouri H., Dimitrov G., Robinson J.R., Mulligan S.,
RA   Walker R.L., Elzer P.E., Hassan K.A., Paulsen I.T.;
RT   "Genome degradation in Brucella ovis corresponds with narrowing of its host
RT   range and tissue tropism.";
RL   PLoS ONE 4:E5519-E5519(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000708; ABQ61097.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5VN83; -.
DR   SMR; A5VN83; -.
DR   EnsemblBacteria; ABQ61097; ABQ61097; BOV_0142.
DR   KEGG; bov:BOV_0142; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000006383; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..898
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335124"
FT   BINDING         646..653
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   898 AA;  97440 MW;  002FA094D3400804 CRC64;
     MENAGPDAPV RLTPMMEQYI EIKAANVDSL LFYRMGDFYE LFFDDAVAAS AALGITLTKR
     GKHLGEDIPM CGVPVHAADD YLQKLIAKGY RVAVCEQVED PAEAKKRGSK SVVKRDVIRL
     VTPGTLTEEK LLDPAQANFL MAMGRTRGDG ALALAWIDIS TGTFRVAETT PDRLFADIMR
     VDPRELVVAD SAFHDEELRP VFDLIGKAVT PQPATLFDSA AAQTRIQHYF NVATLDGFGQ
     FSRPELSAIS GAIAYIEKTQ ISERPPLMRP EREHEGGTLF IDPATRASLE LARTMSGKRD
     GSLLKAIDRT VTGGGARLLA ERLTAPLTSP KEIAPRLDSV SWCLSEQTLC EALRLELKGV
     PDMPRALSRL AVGRGGPRDL GALACGFEAA GGIASLLDGA LLPDELAAAR EAIEKMPAGF
     AAHLDRALAD ELPLLKRDGG FVREGYNSEL DEMRALRDQS RRVIAGLQAD YIEETGIKSL
     KIKHNNVLGY FIEVTANNSG AMTDTDEAKS RFIHRQTMAN AMRFTTTELA ELESKIANAA
     DRALSIELAI FEELTAEAVA HADSIRAAAS ALSVFDVSTA LAVLAEEQGY CRPHVDDSLS
     FNIVAGRHPV VEQALRRQAA NPFVANDCDL SPQRDGGDGA IWLLTGPNMG GKSTFLRQNA
     LIAILAQMGS FVPAGSAHIG VVDRLFSRVG ASDDLARGRS TFMVEMVETA AILNQAGEHS
     LVILDEIGRG TATFDGLSIA WAAVEYLHEK NRCRALFATH FHEMTALSEK LERLSNVTMR
     VKEWDNDVIF LHEVAKGAAD RSYGVQVARL AGLPEAVVNR ARDVLHQLEA GETSGKADRL
     IDDLPLFSVM LQQEKPKPQI QAKDSELANA VAAISPDELT PREALDLIYK LKELAGKA