ID   MUTS_BUCA5              Reviewed;         802 AA.
AC   B8D9K7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BUAP5A_422;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=563178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=5A;
RX   PubMed=19150844; DOI=10.1126/science.1167140;
RA   Moran N.A., McLaughlin H.J., Sorek R.;
RT   "The dynamics and time scale of ongoing genomic erosion in symbiotic
RT   bacteria.";
RL   Science 323:379-382(2009).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001161; ACL30778.1; -; Genomic_DNA.
DR   RefSeq; WP_009874382.1; NC_011833.1.
DR   AlphaFoldDB; B8D9K7; -.
DR   SMR; B8D9K7; -.
DR   KEGG; bap:BUAP5A_422; -.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000006904; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..802
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000192200"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   802 AA;  92589 MW;  B04AFF6EAA6B0987 CRC64;
     MKKKNIKNSM NNHTPMIKQY LSLKSQYPDM LLFYQMGDFY ELFYEDAERI SELLKITLTK
     KGYSNHKIIP MAGVPCHKSE YYLSKLVKLG ESIAICDQQK ETDCKKKLIS RKVVRIITPG
     TVTDEVLLEE NEDNFIAAIW KENNQFGYSV LDLSLGFFGV SKIFSSCDLL SEIERTNPKE
     ILYPENFSDV FLIESRKCIR KRSLLEFDLE TSYKLLNLQF NTCSLDGFGI EKNNFVIRAA
     GCLLQYVKSM NMTVLPNIRQ LKYNYMEDSI FMNFSTRKSL EITQNISGEK KNTLSAILNK
     TVTSMGSRML NRWLNSPLKN FKIVRNRHES VEALKFFYKE LQFILRQVND LERIYSRLAL
     RTASPHDFVR MRSTLEILPN LHLILKKIKS KHIKKIRLSI GYFEEVLCLL KKAISLKPSK
     CIRDGGVIAE LYNIELDELR SIKINSKEYI KNFEQKEKKK LMIESFKIKF NKIIGYYIQI
     SKRHTHLIPK YYVIIQTLKN TERYSVPLLK EYEEKVLNSE MRSLLLEKKL YAEIFNIIEP
     FLEKLQNSAL ALSELDVLVN LSERAISLNY TRPIMSEKYG ISLLESRHPV VECFLKTPFI
     KNSVFLSRTQ RMIIITGPNM GGKSTYMRQI ALIVIMAGIG SFVPARYALI GSIDKIFTRI
     GSADDLSNGY STFMMEMMEI SNILHNATSN SLVLIDELGR GTSTNEGLSL AWSCSRYLIN
     INKSMTLLST HFVELTKLEE KEKFVKNFHF SAIKSDLHIA FLYKIKNGIS KKSYGISVAS
     LSGLPDSVLE DAEKKLIEIE NT