ID   MUTS_BUCAI              Reviewed;         802 AA.
AC   P57504;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=BU429;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; BA000003; BAB13127.1; -; Genomic_DNA.
DR   RefSeq; NP_240241.1; NC_002528.1.
DR   RefSeq; WP_010896112.1; NC_002528.1.
DR   AlphaFoldDB; P57504; -.
DR   SMR; P57504; -.
DR   STRING; 107806.10039093; -.
DR   EnsemblBacteria; BAB13127; BAB13127; BAB13127.
DR   KEGG; buc:BU429; -.
DR   PATRIC; fig|107806.10.peg.438; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..802
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115079"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   802 AA;  92619 MW;  CBCD7179ABB69D20 CRC64;
     MKKKNIKNSM NNHTPMIKQY LSLKSQYPDM LLFYQMGDFY ELFYEDAERI SELLKITLTK
     KGYSNHKIIP MAGVPCHKSE YYLSKLVKLG ESIAICDQQK ETDCKKKLIS RKVVRIITPG
     TVTDEVLLEE NEDNFIAAIW KENNQFGYSV LDLSLGFFGV SKIFSSCDLL SEIERTNPKE
     ILYPENFSDV FLIESRKCIR KRSLLEFDLE TSYKLLNLQY NTCSLDGFGI EKNNFVIRAA
     GCLLQYVKSM NMTLLPNIRQ LKYNYMEDSI FMNFSTRKSL EITQNISGEK KNTLSAILNK
     TVTSMGSRML NRWLNSPLKN FKIVRNRHES VEALQFFYKE LQFILRQVND LERIYSRLAL
     RTASPHDFVR MRSTLEILPN LHLILKKIKS KHIKKIRLSI GYFEEVLCLL KKAISLKPSK
     CIRDGGVIAE LYNIELDELR SIKINSKEYI KNFEQKEKKK LMIESFKIKF NKIIGYYIQI
     SKRHTHLIPK YYVIIQTLKN TERYSVPLLK EYEEKVLNSE MRSLLLEKKL YAEIFNIIEP
     FLEKLQNSAL ALSELDVLVN LSERAISLNY TRPIMSEKYG ISLLESRHPV VECFLKTPFI
     KNSVFLSRTQ RMIIITGPNM GGKSTYMRQI ALIVIMAGIG SFVPARYALI GSIDKIFTRI
     GSADDLSNGY STFMMEMMEI SNILHNATSN SLVLIDELGR GTSTNEGLSL AWSCSRYLIN
     INKSMTLLST HFVELTKLEE KEKFVKNFHF SAIKSDLHIA FLYKIKNGIS KKSYGISVAS
     LSGLPDSVLE DAEKKLIEIE NT