ID   MUTS_BUCAP              Reviewed;         805 AA.
AC   Q8K9D2;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=BUsg_414;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE013218; AAM67959.1; -; Genomic_DNA.
DR   RefSeq; WP_011053926.1; NC_004061.1.
DR   AlphaFoldDB; Q8K9D2; -.
DR   SMR; Q8K9D2; -.
DR   STRING; 198804.BUsg_414; -.
DR   EnsemblBacteria; AAM67959; AAM67959; BUsg_414.
DR   KEGG; bas:BUsg_414; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..805
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115080"
FT   BINDING         617..624
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   805 AA;  92255 MW;  8362204C8ED63C06 CRC64;
     MTETNFSTKN SNHTPMIKQY LSLKSQYPNM LLFYQMGDFY ELFYEDAKRV SRLLKITLTK
     KGNSNNNIIP MAGVPCHTAE YYLSKLVKMG ESIAVCDQIK DVYSEKKLLT RQVVRVITPG
     TITDEAFLEE NKDNFIAAVW KENNKFAYAI LDISLGFFGV SEHFDRNSLL SEIERTNPTE
     LLYPENFEDM LLISHKKCIQ KRPLLDFDIK ISYKLLTLQF KTSNLNGFGI KKNHFVIRPA
     GCLINYIKLM HISFLPHIRK IQFNYIENNI FMNSSTRKSL EIIESISGES KNTLSSVLNK
     TVTSMGGRLL NRWLNTPSKD LSLIKNRHGM VKLLRPFYKE IQCILRQVSD LERICSRLAL
     RTALPRDFVR MRSTLNILPD LCLILKKIKS TSINNVLMSI GKFEKILFLL KKSINLTVPS
     SIRDGGVIAC NYNKKLDELR SLKKNSQKYL QDFEVKEKSR LNIDSFKIGY NNIVGYYIQV
     NKRHSHLIPH SYLKIQTLKN VERYSVPLLK NYEKQVISAK FQAIFLEKTL YMELFDIIEP
     FLEDLKNSAF ALSELDVLVN LSERSISLNY VCPKMTKKYG ITLVESRHPV VECFLENPFI
     SNSVDLSKKN RMLIITGPNM GGKSTYMRQV ALIIIMACIG SFVPAKYASI GLIDKIFTRI
     GSADDVSNGY STFMMEMTEI SNILHNATCN SLILIDELGR GTSNKDGLAL AWSCSKYLMT
     KNKSMILLST HFIELTKLEN FFKNIKNFYF SAFEHDSNIA FLYKIKKGIS KKSYGIAVAS
     LSGIPDIVIQ DAKKKLIELE SDNVF