ID   MUTS_BUCBP              Reviewed;         800 AA.
AC   Q89AD3;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=bbp_380;
OS   Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=224915;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bp;
RX   PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA   van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA   Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA   Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT   "Reductive genome evolution in Buchnera aphidicola.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE016826; AAO27092.1; -; Genomic_DNA.
DR   RefSeq; WP_011091493.1; NC_004545.1.
DR   AlphaFoldDB; Q89AD3; -.
DR   SMR; Q89AD3; -.
DR   STRING; 224915.bbp_380; -.
DR   PRIDE; Q89AD3; -.
DR   EnsemblBacteria; AAO27092; AAO27092; bbp_380.
DR   GeneID; 56470917; -.
DR   KEGG; bab:bbp_380; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000601; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..800
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115081"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   800 AA;  92044 MW;  611B69B94560A083 CRC64;
     MSKIIMNKKN NDTPMIKQYL SLKLHYPNMF LFYRLGDFYE LFFDDAKRIS LMLDITLTKR
     GYSSQKEIPM AGIPYTSLNR YLSKLLKIGE SAVICEQTHI IDKRTGLIER KISRVVTPGT
     VIDEEFLSET KNNLLGSVYY SKKRFGYATL DLCSGNFYIS EYDTFESFIS ELQRTDPEEL
     LIQEDFLYMN FFEKRKGIRL CKLNDFNIDS AYQQLKCHFK TKNLKSFGVY QNNLAISAAG
     CLLKYLKFIQ YSLLPHVKSI KVRYDCNHIF MNSATRKNLE IINNISGKKE HTLLSILDNT
     ATPMGGRLLR KWLSAPIKDI KIINKRHNII KSLKTVYMSL SLLLKGIGDL ERIISRIACR
     SASPKDFVSM RSALLQFSKI IFVLNSTKSK TLELISCKIK EYNSILILLR RSLKVCPSKT
     IKEGNVISEN YNKDLDKWRK IANNASEYLQ YFEVSERKRL HITSLKVNNN RVLGYYVQIS
     KKDIKLAPNN YKKIQTLKHC VRYSTLELLD YENNVNNAKD KVLEIENYLY NELFDFIIPY
     IDSLKISVNT ISELDVLNNL TERACVLNYV CPVISDEYGI LLTDSRHPVV ENLLKTPFVK
     NSINLSKSSN MLIITGPNMG GKSTYMRQIA LIVIMAYIGS FVPAKYARIG LCDKIFTRIG
     SADNLAYGES TFMMEMIEMS SILRNSTSNS LVLIDELGRG TSMHDGLSLA WACIEYLAGK
     INAMTLFSTH YFELTKLKNY YSNIRNMYFD VLEHNNEIVF TYVIKNGFIN KSYGLVVAAL
     AKLPKCILLS AKKKLKEFYP