ID   MUTS_BURA4              Reviewed;         885 AA.
AC   B1YSP3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=BamMC406_1998;
OS   Burkholderia ambifaria (strain MC40-6).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=398577;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MC40-6;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Lang D., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., Ramette A.,
RA   Konstantinidis K., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia ambifaria MC40-6.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001025; ACB64479.1; -; Genomic_DNA.
DR   RefSeq; WP_012364196.1; NC_010551.1.
DR   AlphaFoldDB; B1YSP3; -.
DR   SMR; B1YSP3; -.
DR   EnsemblBacteria; ACB64479; ACB64479; BamMC406_1998.
DR   KEGG; bac:BamMC406_1998; -.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001680; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..885
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093609"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   885 AA;  95842 MW;  972EB258FC9434F7 CRC64;
     MTTLSPEAFA GHTPMMQQYL RIKADHPDTL VFYRMGDFYE LFFEDAEKAA RLLDLTLTQR
     GASAGTPIKM AGVPHHAVEQ YLAKLVKMGE SVAICEQIGD PATSKGPVER KVVRVVTPGT
     LTDAALLSDK NDVYLLAMCT GHNKRGVAVN IGLAWLNLAS GALRLAEIEP DQLGAALERI
     RPAEILTADG ATDTVPAGAG AIKRVPAWHF DIASGTQRLC DQLDVAGLDG FGAHSLTSAC
     GAAGALLLYA AATQGQQLRH VRSLKVENET EYIGLDPATR RNLELTETLR GTESPTLYSL
     LDTCCTTMGS RLLRHWLHHP PRASVAAQSR QQAIGALLDA PADASLDALR SALRQIADVE
     RITGRLALLS ARPRDLSSLR DTFAALPALR ERISAIVANA DALTRVDAAL APPAECLDLL
     TSAIAPEPAA MVRDGGVIAR GYDAELDELR DISENCGQFL IDLEARERTR TGIANLRVEY
     NKVHGFYIEV TRGQTDKVPD DYRRRQTLKN AERYITPELK TFEDKALSAQ ERALARERAL
     YDGVLQALLP FIPECQRVAS ALAELDVLAA FAERARTLDW VAPTFTDEIG IEIEQGRHPV
     VEAQVEQFIA NDCRFGAERK LLLITGPNMG GKSTFMRQTA LIALMAYVGS YVPAKSACFG
     PIDRIFTRIG AADDLAGGRS TFMVEMTEAA AILNDATPQS LVLMDEIGRG TSTFDGLALA
     WAIARHLLAQ NGCYTLFATH YFELTQLPAE FPQAANVHLS AVEHGHGIVF LHAVNEGPAN
     QSYGLQVAQL AGVPAPVIRA ARKHLAYLEQ QSATQNTPQL DLFSAPPAAA DELECADAPA
     VSAIPHPALE KLRDIDPDDL KPRDALDLLY ELRTLVRSHD ADGHA