ID   MUTS_BURCH              Reviewed;         885 AA.
AC   A0K8L2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Bcen2424_2088;
OS   Burkholderia cenocepacia (strain HI2424).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=331272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HI2424;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA   Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., LiPuma J.J., Gonzalez C.F.,
RA   Konstantinidis K., Tiedje J.M., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia cenocepacia HI2424.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000458; ABK08839.1; -; Genomic_DNA.
DR   RefSeq; WP_011694318.1; NC_008542.1.
DR   AlphaFoldDB; A0K8L2; -.
DR   SMR; A0K8L2; -.
DR   KEGG; bch:Bcen2424_2088; -.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..885
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008049"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   885 AA;  95939 MW;  73EC6E608D8B94EC CRC64;
     MTTLSPEAFA GHTPMMQQYL RIKADHPDTL VFYRMGDFYE LFFEDAEKAA RLLDLTLTQR
     GASAGTPIKM AGVPHHAVEQ YLAKLVKMGE SVAICEQIGD PATSKGPVER KVVRVVTPGT
     LTDAALLSDK NDVYLLAMCT GHNKRGVAVN IGLAWLNLAS GALRLAEIEP DQLAAALERI
     RPAEILTPDG ATDAIPAGAG ASKRVPAWHF DIASGTQRLC DQLDVASLDG FGAHSLTSAC
     GAAGALLLYA AATQGQQLRH VRSLKVENET EYIGLDPATR RNLELTETLR GTESPTLYSL
     LDTCCTTMGS RLLRHWLHHP PRASVAAQSR QQAIGALLDA PANASLDALR SALRQIADVE
     RITGRLALLS ARPRDLSSLR DTFAALPALR ERIGAIVANA DALARVDAAL APPAECLDLL
     TSAIAPEPAA MVRDGGVIAR GYDAELDELR DISENCGQFL IDLEARERAR TGIANLRVEY
     NKVHGFYIEV TRGQTDKVPD DYRRRQTLKN AERYITPELK TFEDKALSAQ ERALARERAL
     YDSVLQALLP FIPECQRVAS ALAELDLLAA FAERARALDW VAPTFTDEIG IEIEQGRHPV
     VEAQVEQFIA NDCRFGTERK LLLITGPNMG GKSTFMRQTA LIALMAYVGS YVPAKSACFG
     PIDRIFTRIG AADDLAGGRS TFMVEMTEAA AILNDATPQS LVLMDEIGRG TSTFDGLALA
     WAIARHLLAH NACYTLFATH YFELTQLPAE FPQAANVHLS AVEHGHGIVF LHAVNEGPAN
     QSYGLQVAQL AGVPAPVIRA ARKHLAYLEQ QSASQHTPQL DLFSAPPAAV DDLECADAPA
     LPDTPHPALE KLRDIDPDDL KPREALDLLY ELRTLVRSHD ADGHA