ID   MUTS_BURL3              Reviewed;         885 AA.
AC   Q39EX8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Bcep18194_A5394;
OS   Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 /
OS   R18194 / 383).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=482957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA   Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia sp. 383.";
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000151; ABB08988.1; -; Genomic_DNA.
DR   RefSeq; WP_011352525.1; NC_007510.1.
DR   AlphaFoldDB; Q39EX8; -.
DR   SMR; Q39EX8; -.
DR   EnsemblBacteria; ABB08988; ABB08988; Bcep18194_A5394.
DR   GeneID; 45095276; -.
DR   KEGG; bur:Bcep18194_A5394; -.
DR   PATRIC; fig|482957.22.peg.2346; -.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002705; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..885
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224358"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   885 AA;  95874 MW;  B1939B367FBD4C1F CRC64;
     MTTLSPDAFA GHTPMMQQYL RIKADHPDTL VFYRMGDFYE LFFEDAAKAA RLLDLTLTQR
     GASAGTPIKM AGVPHHAVEQ YLAKLVKMGE SVAICEQIGD PATSKGPVER KVVRVVTPGT
     LTDAALLSDK NDVYLLAMCT GHNKRGVAVN IGLAWLNLAS GALRLAEIEP DQLAAALERI
     RPAEILTPDG ATDAVPAGAG ASKRVPAWHF DIASGTQRLC DQLDVASLDG FGAHSLTSAC
     GAAGALLLYA AATQGQQLRH VRSLKVENET EYIGLDPATR RNLELTETLR GTESPTLYSL
     LDTCCTTMGS RLLRHWLHHP PRASVAAQSR QQAIGALLDA PANASLDALR SALRQIADVE
     RITGRLALLS ARPRDLSSLR DTFAALPALR ERISAIVANA DSLTRVDAAL APPAECLDLL
     TSAIAPEPAA MVRDGGVIAR GYDAELDELR DISENCGQFL IDLEARERTR TGIANLRVEY
     NKVHGFYIEV TRGQTDKVPD DYRRRQTLKN AERYITPELK TFEDKALSAQ ERALARERAL
     YDAVLQALLP FIPECQRVAS ALAELDLLAA FAERASALDW VAPTFTDEIG IEIEQGRHPV
     VEAQVEQFIA NDCRFGTERK LLLITGPNMG GKSTFMRQTA LIALMAYVGS YVPAKSACFG
     PIDRIFTRIG AADDLAGGRS TFMVEMTEAA AILNDATPQS LVLMDEIGRG TSTFDGLALA
     WAIARHLLAH NACYTLFATH YFELTQLPAE FPQAANVHLS AVEHGHGIVF LHAVNEGPAN
     QSYGLQVAQL AGVPAPVIRA ARKHLAYLEQ QSASQHTPQL DLFSAPPVAA DDLECADAPA
     LPDTPHPALE KLRDIDPDDL KPREALDLLY ELRTLVRSHD ADGHA