ID   MUTS_BURM9              Reviewed;         891 AA.
AC   A2SAW7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=BMA10229_A3145;
OS   Burkholderia mallei (strain NCTC 10229).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=412022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 10229;
RX   PubMed=20333227; DOI=10.1093/gbe/evq003;
RA   Losada L., Ronning C.M., DeShazer D., Woods D., Fedorova N., Kim H.S.,
RA   Shabalina S.A., Pearson T.R., Brinkac L., Tan P., Nandi T., Crabtree J.,
RA   Badger J., Beckstrom-Sternberg S., Saqib M., Schutzer S.E., Keim P.,
RA   Nierman W.C.;
RT   "Continuing evolution of Burkholderia mallei through genome reduction and
RT   large-scale rearrangements.";
RL   Genome Biol. Evol. 2:102-116(2010).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABN03149.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000546; ABN03149.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_004199561.1; NC_008836.1.
DR   AlphaFoldDB; A2SAW7; -.
DR   SMR; A2SAW7; -.
DR   EnsemblBacteria; ABN03149; ABN03149; BMA10229_A3145.
DR   KEGG; bml:BMA10229_A3145; -.
DR   HOGENOM; CLU_002472_4_1_4; -.
DR   Proteomes; UP000002283; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..891
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335126"
FT   BINDING         634..641
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   891 AA;  96327 MW;  9176012F727E243A CRC64;
     MATQIDASSE AAAATAAAQH TPMMQQYLRI KSEHPDTLVF YRMGDFYELF FEDAEKAARL
     LDLTLTQRGA SAGTPIKMAG VPHHAVEQYL AKLVKFGESA AICEQIGDPA TSKGPVERKV
     VRVVTPGTLT DAALLSDKSD VFLLALCVGH NKRGVASNIG LAWLNLASGA LRLAELAPDQ
     LGAALERIRP AEILAADGTI ESVPAGMGAI TRVPAWHFDI ASGTQRLCDQ LEVASLDGFG
     AQALTSANGA AGALLIYAAA TQGQQLRHVR SLKVENESEY IGLDPSTRRN LELTETLRGT
     ESPTLYSLLD TCCTAMGSRL LRHWLHHPPR ASVAAQARHQ AIGALLDAPP NAGLDSLRSA
     LRQIADVERI TGRLALLSAR PRDLSSLRDT FAALPALRER VAEIASNAAA LGRLEAALEP
     PPGCLDLLTR AIAAEPAAMV RDGGVIARGY DAELDELRDI SENCGQFLID LETRERARTG
     ISNLRVEYNK VHGFYIEVTR GQTDKVPDDY RRRQTLKNAE RYITPELKTF EDKALSAQER
     ALARERALYD GVLQALLPHI EGCQRVASGL AELDLLAAFA ERARTLDWVA PEFTDEIGIE
     IDQGRHPVVE AQVEQFIAND CALNPERKLL LITGPNMGGK STFMRQTALI ALMAYVGSYV
     PAKAARFGPI DRIFTRIGAA DDLAGGRSTF MVEMTEAAAI LNDATPHSLV LMDEIGRGTS
     TFDGLALAWA IARHLLSHNR CYTLFATHYF ELTQLPAEFP QAANVHLSAV EHGHGIVFLH
     AVEEGPANQS YGLQVAQLAG VPAPVIRAAR KHLAHLEQQS AAQATPQLDL FAAPPVVDEP
     ECNEPPAAAT PHPALERLLE LDPDDLKPRD ALDLLYELHT LARSGPADAQ R