ID   MUTS_BURPS              Reviewed;         890 AA.
AC   Q63SR9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BPSL2252;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; BX571965; CAH36254.1; -; Genomic_DNA.
DR   RefSeq; YP_108847.1; NC_006350.1.
DR   AlphaFoldDB; Q63SR9; -.
DR   SMR; Q63SR9; -.
DR   STRING; 272560.BPSL2252; -.
DR   PRIDE; Q63SR9; -.
DR   EnsemblBacteria; CAH36254; CAH36254; BPSL2252.
DR   KEGG; bps:BPSL2252; -.
DR   PATRIC; fig|272560.6.peg.2559; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000605; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..890
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224356"
FT   BINDING         634..641
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   890 AA;  96255 MW;  080EBC31E48DDB38 CRC64;
     MATQIDASSE AAAATAAAQH TPMMQQYLRI KSEHPDTLVF YRMGDFYELF FEDAEKAARL
     LDLTLTQRGA SAGTPIKMAG VPHHAVEQYL AKLVKFGESA AICEQIGDPA TSKGPVERKV
     VRVVTPGTLT DAALLSDKSD VFLLALCVGH NKRGVASNIG LAWLNLASGA LRLAELAPDQ
     LGAALERIRP AEILAADGTI ESVPAGMGAI TRVPAWHFDI ASGTQRLCDQ LEVASLDGFG
     AQALTSANGA AGALLIYAAA TQGQQLRHVR SLKVENESEY IGLDPSTRRN LELTETLRGT
     ESPTLYSLLD TCCTAMGSRL LRHWLHHPPR ASVAAQARHQ AIGALLDAPP NAGLDSLRSA
     LRQIADVERI TGRLALLSAR PRDLSSLRDT FAALPALRER VAEIASNAAA LGRLEAALEP
     PPGCLDLLTR AIAAEPAAMV RDGGVIARGY DAELDELRDI SENCGQFLID LETRERARTG
     ISNLRVEYNK VHGFYIEVTR GQTDKVPDDY RRRQTLKNAE RYITPELKTF EDKALSAQER
     ALARERALYD GVLQALLPHI EGCQRVASGL AELDLLAAFA ERARTLDWVA PEFTDEIGIE
     IDQGRHPVVE AQVEQFIAND CALNPERKLL LITGPNMGGK STFMRQTALI ALMAYVGSYV
     PAKAARFGPI DRIFTRIGAA DDLAGGRSTF MVEMTEAAAI LNDATPHSLV LMDEIGRGTS
     TFDGLALAWA IARHLLSHNR CYTLFATHYF ELTQLPAEFP QAANVHLSAV EHGHGIVFLH
     AVEEGPANQS YGLQVAQLAG VPAPVIRAAR KHLAHLEQQS AAQATPQLDL FAAPPVVDEP
     ECNEPPAATP HPALERLLEL DPDDLKPRDA LDLLYELHTL ARSGPADAQR