ID   MUTS_BURTA              Reviewed;         893 AA.
AC   Q2SXA6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=BTH_I1913;
OS   Burkholderia thailandensis (strain ATCC 700388 / DSM 13276 / CIP 106301 /
OS   E264).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=271848;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700388 / DSM 13276 / CIP 106301 / E264;
RX   PubMed=16336651; DOI=10.1186/1471-2164-6-174;
RA   Kim H.S., Schell M.A., Yu Y., Ulrich R.L., Sarria S.H., Nierman W.C.,
RA   DeShazer D.;
RT   "Bacterial genome adaptation to niches: divergence of the potential
RT   virulence genes in three Burkholderia species of different survival
RT   strategies.";
RL   BMC Genomics 6:174-174(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000086; ABC37610.1; -; Genomic_DNA.
DR   RefSeq; WP_009890225.1; NZ_CP008785.1.
DR   AlphaFoldDB; Q2SXA6; -.
DR   SMR; Q2SXA6; -.
DR   PRIDE; Q2SXA6; -.
DR   EnsemblBacteria; ABC37610; ABC37610; BTH_I1913.
DR   KEGG; bte:BTH_I1913; -.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000001930; Chromosome I.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..893
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335130"
FT   BINDING         637..644
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   893 AA;  96972 MW;  2A7C87E25C644864 CRC64;
     MDKDVQEITD SKQQLTEAAF SNHTPMMQQY LRIKAEHPET LVFYRMGDFY ELFFEDAEKA
     ARLLDLTLTQ RGASAGTPIK MAGVPHHAVE QYLAKLVKFG ESAAICEQIG DPATSKGPVE
     RKVVRVVTPG TLTDAALLSD KSDVFLLALC VGHNKRGVAS TIGLAWLNLA SGALRLAEIA
     PDQLGAALER IRPAEILAAD GAIEAVPAGT GAITRVPAWH FDIASGTQRL CDQLEVASLD
     GFGAQALTSA NGAAGALLIY AAATQGQQLR HVRSLKVENE SEYIGLDPST RRNLELTETL
     RGTESPTLYS LLDTCCTAMG SRLLRHWLHH PPRASVAAQA RHQAIGALLD APVHVGLDSL
     RSALRQIADV ERITGRLALL SARPRDLSSL RDTFAALPAL RERVAEIAPN AAALGRLEAA
     LEPPPGCLDL LTRAIAPEPA AMVRDGGVIA RGYDAELDEL RDISENCGQF LIDLETRERA
     RTGIPNLRVE YNKVHGFYIE VTRGQTDKVP DDYRRRQTLK NAERYITPEL KTFEDKALSA
     QERALARERA LYDSVLQALL PHIEGCQRVA SGLAELDLLA AFAERARTLD WVAPEFIDEI
     GIEIDQGRHP VVEAQVEQFI ANDCALNSDR KLLLITGPNM GGKSTFMRQT ALIALMAYVG
     SYVPAKAARF GPIDRIFTRI GAADDLAGGR STFMVEMTEA AAILNDATPQ SLVLMDEIGR
     GTSTFDGLAL AWAIARHLLS HNRCYTLFAT HYFELTQLPA EFPQAANVHL SAVEHGHGIV
     FLHAVEEGPA NQSYGLQVAQ LAGVPAPVIR AARKHLAHLE QQSAAQATPQ LDLFAAQPIV
     DEQECNQPPA AAPHPALERL LALDPDDLKP RDALDLLYEL RALARSGATD AQR