ID   MUTS_BURVG              Reviewed;         886 AA.
AC   A4JFW7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Bcep1808_2168;
OS   Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia
OS   (strain R1808)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=269482;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G4 / LMG 22486;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Tiedje J., Richardson P.;
RT   "Complete sequence of chromosome 1 of Burkholderia vietnamiensis G4.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000614; ABO55170.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4JFW7; -.
DR   SMR; A4JFW7; -.
DR   STRING; 269482.Bcep1808_2168; -.
DR   EnsemblBacteria; ABO55170; ABO55170; Bcep1808_2168.
DR   KEGG; bvi:Bcep1808_2168; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_4; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002287; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..886
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335131"
FT   REGION          834..857
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         627..634
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   886 AA;  95964 MW;  149651A0C483B9E9 CRC64;
     MDLSDSPKGI ETHTPMMQQY LRIKADHPDT LVFYRMGDFY ELFFEDAEKA ARLLDLTLTQ
     RGASAGNPIK MAGVPHHAVE QYLAKLVKMG ESVAICEQIG DPATSKGPVE RKVVRVVTPG
     TLTDAALLSD KNDVYLLAMY TGHNKRGVAV NIGLAWLNLA SGALRLAEIE PDQLGAALER
     IRPAEILTAD GATDAVPAGA GAVKRVPAWH FDIASGTQRL CDQLDVAGLD GFGAHSLTSA
     CGAAGALLLY AAATQGQQLR HVRSLKVESE TEYIGLDPAT RRNLELTETL RGTESPTLYS
     LLDTCCTTMG SRLLRHWLHH PPRASVAAQS RQQAIGALLD APADANLDAL RSALRQIADV
     ERITGRLALL SARPRDLSSL RDTFAALPAL RERISAIVAN ADALARVDAA LAPPAECLDL
     LTSAIAPEPA AMVRDGGVIA RGYDAELDEL RDISENCGQF LIDLEARERA RTGIANLRVE
     YNKVHGFYIE VTRGQTDKVP DDYRRRQTLK NAERYITPEL KTFEDKALSA QERALARERA
     LYDGVLQALL PFIPECQRVA SALAELDVLA AFAERARTLD WVAPTFTDDI GIEIEQGRHP
     VVEAQVEQFI ANDCRFGADR KLLLITGPNM GGKSTFMRQT ALIALMAYVG SYVPAKSACF
     GPIDRIFTRI GAADDLAGGR STFMVEMTEA AAILNDATPQ SLVLMDEIGR GTSTFDGLAL
     AWAIARHLLA QNGCYTLFAT HYFELTQLPS EFPQAANVHL SAVEHGHGIV FLHAVNEGPA
     NQSYGLQVAQ LAGVPAPVIR AARKHLAYLE QQSAAQHTPQ LDLFSAPPAA ADDVECADAP
     APSDATHPAL DRLRDIDPDD LKPREALDLL YELRTLVRSH DADGHA