ID   MUTS_CALS4              Reviewed;         869 AA.
AC   Q8RA71;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; Synonyms=mutS2;
GN   OrderedLocusNames=TTE1357;
OS   Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM
OS   11007 / NBRC 100824 / MB4) (Thermoanaerobacter tengcongensis).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Caldanaerobacter.
OX   NCBI_TaxID=273068;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15242 / JCM 11007 / NBRC 100824 / MB4;
RX   PubMed=11997336; DOI=10.1101/gr.219302;
RA   Bao Q., Tian Y., Li W., Xu Z., Xuan Z., Hu S., Dong W., Yang J., Chen Y.,
RA   Xue Y., Xu Y., Lai X., Huang L., Dong X., Ma Y., Ling L., Tan H., Chen R.,
RA   Wang J., Yu J., Yang H.;
RT   "A complete sequence of the T. tengcongensis genome.";
RL   Genome Res. 12:689-700(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE008691; AAM24579.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8RA71; -.
DR   SMR; Q8RA71; -.
DR   STRING; 273068.TTE1357; -.
DR   EnsemblBacteria; AAM24579; AAM24579; TTE1357.
DR   KEGG; tte:TTE1357; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000555; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..869
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115161"
FT   BINDING         619..626
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   869 AA;  99087 MW;  74F6A4F5624A5882 CRC64;
     MLKMSVTPMM EQYLKIKEKY KDAILFFRLG DFYEMFYEDA EIAAKELEIA LTGRDAGTEE
     RAPMAGVPYH AADFYIDKLV KKGYKVAICE QLEDPSKAKG LVKRDVVRIY TPGTIINPES
     MDEKSNNYLV SVYREKDNYG ICAVDVTTGE LYATEIKNCK NGKRIYDEIA KYSPSEIISN
     EEFLKNNKYI KVFKNNNCAV NAYKPLNYEA SSELIEKQFD KKVEELELED KKFVIHSLGA
     LLSYLKELQK TSLKHINKLT LYQDNSYMGL DSNAIRNLEI LESNRNKSKK GSLLGVLDRT
     VTPMGGRLLK KWLEEPLIDK DEIEKRLDAV EELFNNYRER IELKELLNKV YDLERLASKI
     VYQSVTPKDF ISIKLSLQNL PKIKNILSKF SSRLLKEIYE KLDVLQDVYE LIDKSIKDDP
     SNQLKEGNII KDGYNEMVDK LRKASTEGKN WIANLEADER EKTGIKNLRI GYNKVFGYYI
     EVTKSNIPQV PDRYIRKQTL ANAERYVTPE LKEIEETILG AEEKLIELEY ELFNEIREKV
     ELQIVRIQNT AKYIAIIDVL ISFAEVAETN KYVKPIVDYE DRIVIKEGRH PVVETISDEG
     FVANDIDIGP ENPIMIITGP NMAGKSTYMR QVALIVLMAQ VGCFVPASYA RIGIVDKIFT
     RVGASDDIFA GQSTFMVEMS EVANILHSAT SKSLIILDEV GRGTSTYDGM SIAQAVIEYI
     HEKIKAKTLF ATHYHELTKL EGKLRGVRNF NVSVEEREDD IIFLHKIVPG GSDRSYGIQV
     SKLAGLPYSI IERAKEILEA LERDKAVKNE LEEAVSQFAF TQIDIFSSAK DALIEEIANC
     DPDNMTPLQA LTYLYKLKEK AASLRSGVI