MUTS_CALS8
ID MUTS_CALS8 Reviewed; 863 AA.
AC A4XL47;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Csac_2047;
OS Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T
OS 6331).
OC Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX NCBI_TaxID=351627;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A.,
RA VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J.,
RA Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M.,
RA Kengen S.M.W., Richardson P.;
RT "Genome sequence of the thermophilic hydrogen-producing bacterium
RT Caldicellulosiruptor saccharolyticus DSM 8903.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000679; ABP67632.1; -; Genomic_DNA.
DR RefSeq; WP_011917567.1; NC_009437.1.
DR AlphaFoldDB; A4XL47; -.
DR SMR; A4XL47; -.
DR STRING; 351627.Csac_2047; -.
DR PRIDE; A4XL47; -.
DR EnsemblBacteria; ABP67632; ABP67632; Csac_2047.
DR KEGG; csc:Csac_2047; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_9; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 15991at2; -.
DR Proteomes; UP000000256; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..863
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000071272"
FT BINDING 607..614
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 863 AA; 99249 MW; 1ACF9682F656BEDF CRC64;
MQELTPMMQQ YMEIKQRVKD CILFFRLGDF YEMFFDDAII ASKELEIALT ARDCGNNEKA
PMCGVPYHSA HSYIAKLIEK GYKVAICEQV EDPKLAKGVV KREITRIITP GTFIDENFSK
ANNFICCVAR VESDFALTFV DISTGEMYAC LIENDIQKMI NEISKYAPSE ILISHLDNEL
YEVIRENYNS FVQRIEFIEI DRCYDLIDKQ MQITNINDKV ALSVGNLLNY LVDTQKISFN
YIKKFEFYRV QNYLQIDLST KRNLELTESI IARSKKNSLF GILDQAKTSM GSRLIKKWLE
RPLIDVVEIN RRLDAVEELY NNFPLLMQIE GLLEGIYDIE RLSSKFAYKS INAKDLLSLK
KSIEVLPRLK ELLGEFKSPL LKELYNELDT LEDVYSLIDS SINEDAPVGL KEGGIIKDGF
NDHVDRLRNI SKNSKELLIQ YEEKERNLTG IKNLKIGYNK VFGYYIEVTK SNYSLVPERY
IRKQTLANAE RYVTEELKKL EDEIINAEQK LVELEYELFC QIRDKIESQI ERIQKTASCI
AIIDALCSFA HIAIDNRYTK PIVYLGDRIY IKNGRHPVVE KMIGYSNFVP NDTELDNDQN
RVLIITGPNM AGKSTYMRQV ALIVIMAQMG CFVPAEEAQI GIVDKIFSRI GASDDISSGQ
STFMVEMSEV ANILKNATPK SLIIFDEVGR GTSTYDGLSI AWAVLEFVAD KSKIGAKTLF
ATHYHELTEL EEKISGVKNY RVDVKEEGKN IIFLRKIVRG GCDSSYGIHV ARLAGIPEEV
LQRAEQILKK LEEADINRKE AKRLRKEIKR EFTEQIEFFS YKKDEIIEKI ENLDILNITP
IQALNILSEL KHEIIKAKER QLL