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MUTS_CALS8
ID   MUTS_CALS8              Reviewed;         863 AA.
AC   A4XL47;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Csac_2047;
OS   Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T
OS   6331).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Caldicellulosiruptor.
OX   NCBI_TaxID=351627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43494 / DSM 8903 / Tp8T 6331;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Lykidis A., van de Werken H.J.G., Verhaart M.R.A.,
RA   VanFossen A.L., Lewis D.L., Nichols J.D., Goorissen H.P., van Niel E.W.J.,
RA   Stams F.J.M., Willquist K.U., Ward D.E., van der Oost J., Kelly R.M.,
RA   Kengen S.M.W., Richardson P.;
RT   "Genome sequence of the thermophilic hydrogen-producing bacterium
RT   Caldicellulosiruptor saccharolyticus DSM 8903.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000679; ABP67632.1; -; Genomic_DNA.
DR   RefSeq; WP_011917567.1; NC_009437.1.
DR   AlphaFoldDB; A4XL47; -.
DR   SMR; A4XL47; -.
DR   STRING; 351627.Csac_2047; -.
DR   PRIDE; A4XL47; -.
DR   EnsemblBacteria; ABP67632; ABP67632; Csac_2047.
DR   KEGG; csc:Csac_2047; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000256; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..863
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000071272"
FT   BINDING         607..614
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   863 AA;  99249 MW;  1ACF9682F656BEDF CRC64;
     MQELTPMMQQ YMEIKQRVKD CILFFRLGDF YEMFFDDAII ASKELEIALT ARDCGNNEKA
     PMCGVPYHSA HSYIAKLIEK GYKVAICEQV EDPKLAKGVV KREITRIITP GTFIDENFSK
     ANNFICCVAR VESDFALTFV DISTGEMYAC LIENDIQKMI NEISKYAPSE ILISHLDNEL
     YEVIRENYNS FVQRIEFIEI DRCYDLIDKQ MQITNINDKV ALSVGNLLNY LVDTQKISFN
     YIKKFEFYRV QNYLQIDLST KRNLELTESI IARSKKNSLF GILDQAKTSM GSRLIKKWLE
     RPLIDVVEIN RRLDAVEELY NNFPLLMQIE GLLEGIYDIE RLSSKFAYKS INAKDLLSLK
     KSIEVLPRLK ELLGEFKSPL LKELYNELDT LEDVYSLIDS SINEDAPVGL KEGGIIKDGF
     NDHVDRLRNI SKNSKELLIQ YEEKERNLTG IKNLKIGYNK VFGYYIEVTK SNYSLVPERY
     IRKQTLANAE RYVTEELKKL EDEIINAEQK LVELEYELFC QIRDKIESQI ERIQKTASCI
     AIIDALCSFA HIAIDNRYTK PIVYLGDRIY IKNGRHPVVE KMIGYSNFVP NDTELDNDQN
     RVLIITGPNM AGKSTYMRQV ALIVIMAQMG CFVPAEEAQI GIVDKIFSRI GASDDISSGQ
     STFMVEMSEV ANILKNATPK SLIIFDEVGR GTSTYDGLSI AWAVLEFVAD KSKIGAKTLF
     ATHYHELTEL EEKISGVKNY RVDVKEEGKN IIFLRKIVRG GCDSSYGIHV ARLAGIPEEV
     LQRAEQILKK LEEADINRKE AKRLRKEIKR EFTEQIEFFS YKKDEIIEKI ENLDILNITP
     IQALNILSEL KHEIIKAKER QLL
 
 
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