ID   MUTS_CARHZ              Reviewed;         841 AA.
AC   Q3ACA5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CHY_1397;
OS   Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS   Z-2901).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Carboxydothermus.
OX   NCBI_TaxID=246194;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901;
RX   PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA   Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA   Madupu R., Sullivan S.A., Kolonay J.F., Nelson W.C., Tallon L.J.,
RA   Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B., Robb F.T., Eisen J.A.;
RT   "Life in hot carbon monoxide: the complete genome sequence of
RT   Carboxydothermus hydrogenoformans Z-2901.";
RL   PLoS Genet. 1:563-574(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000141; ABB14144.1; -; Genomic_DNA.
DR   RefSeq; WP_011344304.1; NC_007503.1.
DR   AlphaFoldDB; Q3ACA5; -.
DR   SMR; Q3ACA5; -.
DR   STRING; 246194.CHY_1397; -.
DR   PRIDE; Q3ACA5; -.
DR   EnsemblBacteria; ABB14144; ABB14144; CHY_1397.
DR   KEGG; chy:CHY_1397; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002706; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..841
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224359"
FT   BINDING         600..607
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   841 AA;  95443 MW;  BC22C6E47D4E9D00 CRC64;
     MSFTPMMKQY LDIKKQYSDC LLFFRLGDFY ELFFEDAVIA SRELEIVLTG RDAGQEERVP
     MCGVPYHSAQ GYIAKLLSRG YKVAICEQVE DPKKAKGLVK REVTKIYTPG TVTEEFFLQE
     KTNNYIIALA EKDGLIALAV AEVSTGYLGI TSVDEGKIEV LASEIRRLAP TEAVVLKNFK
     NNFLLKDITG IVNYLEKLPA EEIEIAFKGP EASKEAYKIL ISYLKRIEPA VLSIFGQPEF
     YQIDSYLYFD ESTRKNLEIL RNREDNSSSL LGIIDFTQTA MGARKLKEEL TKPLLNLKAI
     ADRLDAVEIL VNDYELRENL RENLKNLYDL ERLSIKLVCG TINPKDLIKI KQSLPQIWHI
     KNSINHVKNK SVLFAEIYKN LPEMREVYNL IDKSIVDDPP VSPKDGGIIK NGYNPTVDEY
     RKAREEGQDW IINYEKKERE RTGIKSLKVN YNKVFGYFIE VTKANLHLVP ADYQRKQTMV
     NAERFITEEL KHYENLILGA SEKLANLEYE LFCEIRSEIL KYQEDLKRAA SAVALLDFLI
     SLAVAAIEYD FTRPVITAEP VLEIKNGRHP VVEKSVGRAN FVPNDLYLDT KENSLLLITG
     PNMAGKSTYM RQAALIVILA QIGSFVPAEY ARVGLVDKIL TRIGATDDLA KGQSTFMVEM
     IECNNILRNA TSRSLILLDE VGRGTSTYDG ISIAEAIIEY IQKKIKARTL FSTHYHELTG
     LEGEIPGVKN FTVLVQEKGE EVKFLHKVVP GKTDKSYGIY VAKLAGLPRE VVERAYEILA
     RFEDKGLKVK DTVPVQLSLF EEKPEPSGVI KELIELDLIR MTPLEALNKL YELRQKALGE
     K