ID   MUTS_CAUSK              Reviewed;         904 AA.
AC   B0T142;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Caul_0008;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter; unclassified Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K31;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T.,
RA   Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000927; ABZ69146.1; -; Genomic_DNA.
DR   RefSeq; WP_012284104.1; NC_010338.1.
DR   AlphaFoldDB; B0T142; -.
DR   SMR; B0T142; -.
DR   STRING; 366602.Caul_0008; -.
DR   EnsemblBacteria; ABZ69146; ABZ69146; Caul_0008.
DR   KEGG; cak:Caul_0008; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..904
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335133"
FT   BINDING         654..661
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   904 AA;  95753 MW;  4DD05B81F3946A65 CRC64;
     MNAPASPAVQ TYDATGATPV MQQFFEMKAR HPDALIFFRM GDFYELFFDD AYKAAAALGI
     SQTFRGTHNG QPIPMAGVPQ HAAEAYLSKL IRLGFKVAVC EQMEDPAEAR KRGSKSVVRR
     DIVRVVTPGT LTEDGLLDAR GANRLAAVAI RAGQAAVAAV ELSTGEVECF LVAKDAVGAI
     LAALAPSETL VADRLLSDDL LAQTLKICGG LIQPMPSALS EPQASETRVK RLYGVDTLDG
     FGGLSAAEIG ALGLIAAHLE MTQAGKLPAL RAPRRAAEAD VMSIDPATRS SLEIDRAQNG
     DRSGSLLAAI DRTVTAGGAR MLASRLARPL LDPHAIDARL DAVEWFVDHR GLRERLREVL
     KGAGDMARAL SRLALGRGGP RDLGCLKDGL KTGEKLAGMV GGSGDPLSPP PAQLEGALKA
     LTPSLQEGLS RLLAQLETGL GPDLPALARD GGYVAAGVRP ELDQARALRD DSRRVVAALE
     SRLIQESGVP LKIRHNGVLG YFVEATAGKA DPLFQPPLNA TFIHRQTLAN QVRFTTVELA
     DLDARIAQAA ERALAMEVAA FEDWRAEAVA LAEPIQLAAE ALAKLDVAAA LAEWAEDAGA
     VRPSVDKSLA FEARAARHPV VEAAVKRAGD PYTPNDCCLD AAGERGARLS IVTGPNMAGK
     STFLRQNAIL AILAQSGCYV PAKSLRLGVI DRLFSRVGAG DDLARGRSTF MMEMVETAAI
     LTQASPRSLV ILDEIGRGTA TYDGLAIAWA CAEALHDTNR CRALFATHYH ELATLETRLA
     HVSNLSLRAK EWNGDLVFLH EAAAGPADRS YGVQVAKLAG VPPAVVARAK EVLDRLESKT
     ESPARLDDLP LFASHAPGPL NQFGAPVQAA PSRTDAALGD LDVDGMSPRE ALDALYRLKA
     LLKT