ID   MUTS_CAUVC              Reviewed;         903 AA.
AC   Q9AC54;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CC_0012;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE005673; AAK22000.1; -; Genomic_DNA.
DR   PIR; D87250; D87250.
DR   RefSeq; NP_418832.1; NC_002696.2.
DR   RefSeq; WP_010917902.1; NC_002696.2.
DR   AlphaFoldDB; Q9AC54; -.
DR   SMR; Q9AC54; -.
DR   STRING; 190650.CC_0012; -.
DR   EnsemblBacteria; AAK22000; AAK22000; CC_0012.
DR   KEGG; ccr:CC_0012; -.
DR   PATRIC; fig|190650.5.peg.13; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; CAULO:CC0012-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..903
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115082"
FT   BINDING         655..662
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   903 AA;  96008 MW;  C98D16803C703987 CRC64;
     MNAHATPTPA HEIDPTGATP VMAQFFEMKA RQPDALIFFR MGDFYELFFD DAYKAAAALG
     ISQTFRGTHN GQPIPMAGVP QHAAEAYLSK LIRLGFKVAV CEQMEDPAEA KKRGSKAVVR
     RDIVRVVTPG TLTEDGLLDA RGANRLAAVA LRAGQAAVAS VELSTGEVEV LAVAKEGVAP
     ILAALAPSET LVADRLLSDD SLSQTLRICG GLVQPMPSAL SEPQASETRV KRLYGVETLD
     GFGGLSPAEI GALGLIAAHL EMTQAGRLPA LRAPRRAADA DVMAIDPATR SSLEIDRTQS
     GDRNGSLLAA IDRTVTAGGA RMLASRLARP LLDVAAIDQR LDAVEWFVEH RQLRQRLREV
     LKGAGDMARA LSRLALGRGG PRDLGCIRDT LKVGERLAGM AGGAPDPLSP PPFELEHAFK
     ALTPALHEGL SQFLTTLEHG LGPDLPALAR DGGFVAAGVR PELDQARGLR DDSRKVIAAL
     ESQLALESGV PLKIRHNGVL GYFVEATAGK ADPLFQPPLN ATFIHRQTLA NQVRFTTVEL
     ADLDARIAQA AERALAMEVA AFEDWREQAR LLADAIQIAS EALARIDVAS SLAEWAEDAG
     AVRPVVDASY AFDAKAARHP VVEAAVKRAG EPYTPNDCRL DASGETAARL SIVTGPNMAG
     KSTFLRQNAL LAILAQSGCY VPAASFRLGV VDRLFSRVGA GDDLARGRST FMMEMVETAS
     ILTQAGPRSL VILDEIGRGT ATYDGLAIAW ACAEALHDTN RCRALFATHY HELATLETRM
     AFVSNLSLRA KEWNGDLVFL HEAAPGPADR SYGVQVAKLA GVPAPVVVRA REVLDRLESK
     DQSPAKLDDL PLFAVSQAVA VTSAPAKAAP SAVETSLADL DVDGMSPREA LEALYRLKGL
     LTA