ID   MUTS_CERS1              Reviewed;         880 AA.
AC   A3PNR5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Rsph17029_2879;
OS   Cereibacter sphaeroides (strain ATCC 17029 / ATH 2.4.9) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=349101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17029 / ATH 2.4.9;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.,
RA   Mackenzie C., Choudhary M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides ATCC 17029.";
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000577; ABN77981.1; -; Genomic_DNA.
DR   RefSeq; WP_011841938.1; NC_009049.1.
DR   AlphaFoldDB; A3PNR5; -.
DR   SMR; A3PNR5; -.
DR   EnsemblBacteria; ABN77981; ABN77981; Rsph17029_2879.
DR   GeneID; 57471549; -.
DR   KEGG; rsh:Rsph17029_2879; -.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..880
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335212"
FT   REGION          835..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         631..638
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   880 AA;  96059 MW;  1FDDE7B15DC158A1 CRC64;
     MEGGSVSDDT VTPMMAQYLE IKAQNPGAIL FYRMGDFYEM FFDDAALAAE ALDIALTKRG
     KHRGEDIAMC GVPIHAAEGY LLTLIRKGFR VAIAEQMEDP AEAKKRGSKS VVRREVVRLV
     TPGTLTEDTL LEARRHNYLC AFAEIRDEAA LAWADISTGE LSVTACPLPR LMPELARLAP
     RELLVADERE LDWIEEVGCA LTPLSRASFD SASAEKRLCA LFGVGTLESF GNFTRAELSA
     MGALVDYLDL TQRGKLPLLR PPVRETVGGT VQIDAATRRN LEITQALAGG RDGSLLSAVD
     RTVTAPGARL LERRLSSPTR DLGLIHERLG AVRWLTEEPR LREEMRASLR RVPDMDRALS
     RLALDRAGPR DMAAIRAGLA QAQEIAQRMP AEAPALVTRA LEALGGHEAL VDLLDQALVA
     EPPLLARDGG FIAQGFDADL DETRRLRDEG RGVIASMQAG FIEVTGIQSL KIKHNNVLGY
     FIEVTSTHAE KMLSAPLSER FIHRQTTAGQ VRFTTVELSE LETRILNAGN RALDLEKMHF
     AALRTAILDL AGQIGRAARS LAELDLISAF ADLAAIEDWT EPEIDDSRAF AIEAGRHPVV
     ERALRRTGTP FVANHCDLST GGTPAVWLIT GPNMAGKSTF LRQNALIALL AQAGSFVPAR
     RAHIGLVSQI FSRVGASDDL ARGRSTFMVE MVETAAILNQ ADDRALVILD EIGRGTATWD
     GLSIAWATLE HLHDRNRCRA LFATHYHEMT ALAGKLKGVE NATVAVKEWE GDVIFLHEVR
     RGAADRSYGV QVARLAGLPA SVIERARTVL DALESGERES GGRRQTLIDD LPLFRAAPPP
     PAPAAPKTSP VEERLREIQP DDLSPREALK LLYDLRALLT