ID   MUTS_CERS4              Reviewed;         875 AA.
AC   Q3IYI5;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=RHOS4_28310;
GN   ORFNames=RSP_1218;
OS   Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG
OS   31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=272943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203
RC   / NCIMB 8253 / ATH 2.4.1.;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C.,
RA   Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000143; ABA80399.1; -; Genomic_DNA.
DR   RefSeq; WP_011338798.1; NZ_AKVW01000001.1.
DR   RefSeq; YP_354300.1; NC_007493.2.
DR   AlphaFoldDB; Q3IYI5; -.
DR   SMR; Q3IYI5; -.
DR   STRING; 272943.RSP_1218; -.
DR   EnsemblBacteria; ABA80399; ABA80399; RSP_1218.
DR   KEGG; rsp:RSP_1218; -.
DR   PATRIC; fig|272943.9.peg.3199; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q3IYI5; -.
DR   Proteomes; UP000002703; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..875
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224398"
FT   REGION          830..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   875 AA;  95718 MW;  BCCDDB772556FEDA CRC64;
     MSDDTVTPMM AQYLEIKAQN PGAILFYRMG DFYEMFFDDA ALAAEALDIA LTKRGKHRGE
     DIAMCGVPIH AAEGYLLTLI RKGFRVAIAE QMEDPAEAKK RGSKSVVRRE VVRLVTPGTL
     TEDTLLEARR HNYLCAFAEI RDEAALAWAD ISTGELSVTA CPLPRLMPEL ARLAPRELLV
     ADERELDWIE EVGCALTPLS RASFDSASAE KRLCALFGVG TLESFGNFTR AELSAMGALV
     DYLDLTQRGK LPLLRPPVRE TVGGTVQIDA ATRRNLEITQ ALAGGRDGSL LSAVDRTVTA
     PGARLLERRL SSPTRDLGLI HERLGAVRWL TEEPRLREEM RASLRRVPDM DRALSRLALD
     RAGPRDMAAI RAGLAQAQEI AQRMPAEAPA LVTRALEALG GHEALVDLLD QALVAEPPLL
     ARDGGFIAQG FDADLDETRR LRDEGRGVIA SMQAGFIEVT GIQSLKIKHN NVLGYFIEVT
     STHAEKMLSA PLSERFIHRQ TTAGQVRFTT VELSELETRI LNAGNRALDL EKMHFAALRT
     AILDLAGQIG RAARSLAELD LISAFADLAV TEDWTEPEID DSRAFAIEAG RHPVVERALR
     RTGTPFVANH CDLSTGETPA VWLITGPNMA GKSTFLRQNA LIALLAQAGS FVPARRAHIG
     LVSQIFSRVG ASDDLARGRS TFMVEMVETA AILNQADDRA LVILDEIGRG TATWDGLSIA
     WATLEHLHDR NRCRALFATH YHEMTALAGK LKGVENATVA VKEWEGDVIF LHEVRRGAAD
     RSYGVQVARL AGLPASVIER ARTVLDALES GERESGGRRQ TLIDDLPLFR AAPPPPAPAA
     PKTSPVEERL REIQPDDLSP REALKLLYDL RALLT