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MUTS_CERS5
ID   MUTS_CERS5              Reviewed;         876 AA.
AC   A4WVX8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Rsph17025_2655;
OS   Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) (Rhodobacter
OS   sphaeroides).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Cereibacter.
OX   NCBI_TaxID=349102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17025 / ATH 2.4.3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M.,
RA   Donohue T.J., Kaplan S.;
RT   "Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000661; ABP71542.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4WVX8; -.
DR   SMR; A4WVX8; -.
DR   STRING; 349102.Rsph17025_2655; -.
DR   PRIDE; A4WVX8; -.
DR   EnsemblBacteria; ABP71542; ABP71542; Rsph17025_2655.
DR   KEGG; rsq:Rsph17025_2655; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   BioCyc; RSPH349102:G1G8M-2735-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..876
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008084"
FT   REGION          829..856
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   876 AA;  95485 MW;  C32E0EB085F39750 CRC64;
     MSDDTVTPMM AQYLEIKAQH PGAILFYRMG DFYEMFFEDA ALAAEALDIA LTKRGKHKGE
     DIAMCGVPIH AAEGYLLTLI RKGFRVAIAE QMEDPAEAKK RGSKSVVRRE VVRLVTPGTL
     TEDSLLEARR HNFLCAFAEI RDEAALAWAD ISTGEFSVTP CPLPRLLPEL ARLAPRELLV
     ADERPLDWIE EVGCALTPLA RASFDSASAE KRLCTLFGVG TLDSFGNFTR PELSAMGALV
     DYLDLTQRGK LPLLRPPVRE VAGGTVQIDA ATRRNLEITQ ALTGGREGSL LSAVDRTVTA
     PGARLLERRL SSPSRDLGLI HDRLAAVSWL TDEPRLREDL RASLRRVPDM DRALSRLALD
     RAGPRDMAAI RAGLTQAEAI AGRMPADAPS LLAETLEALR GHENLVDLLD QALVAEPPLL
     VRDGGFIAPG FDDDLDETRR LRDEGRGVIA SMQAGFIETT GIQSLKIKHN NVLGYFIEVT
     STHAEKMLSP PLSESFIHRQ TTAGQVRFTT VALSELETRI LNAGNRALEL EKMHFAALRT
     AILDQAGAIG RAARALAEVD LIAAFADLAV AEDWTEPQVD DSRAFAIEAG RHPVVERALR
     RTGTPFVAND CDLSKAETPA VWLITGPNMA GKSTFLRQNA LIALLAQAGS FVPARRAHIG
     LVSQIFSRVG ASDDLARGRS TFMVEMVETA AILNQADDRA LVILDEIGRG TATWDGLSIA
     WATLEHLHDT NRCRALFATH YHEMTALAGK LTGVENATVS VKEWQGEVIF LHEVRRGAAD
     RSYGVQVARL AGLPASVIER ARTVLDALES GERESGPRRQ ALIDDLPLFR AAPPPPAPAA
     PPKASQVEER LRAIQPDDLS PREALKLLYD LRALLP
 
 
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