MUTS_CERS5
ID MUTS_CERS5 Reviewed; 876 AA.
AC A4WVX8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Rsph17025_2655;
OS Cereibacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) (Rhodobacter
OS sphaeroides).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC Rhodobacteraceae; Cereibacter.
OX NCBI_TaxID=349102;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17025 / ATH 2.4.3;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Richardson P., Mackenzie C., Choudhary M.,
RA Donohue T.J., Kaplan S.;
RT "Complete sequence of chromosome of Rhodobacter sphaeroides ATCC 17025.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000661; ABP71542.1; -; Genomic_DNA.
DR AlphaFoldDB; A4WVX8; -.
DR SMR; A4WVX8; -.
DR STRING; 349102.Rsph17025_2655; -.
DR PRIDE; A4WVX8; -.
DR EnsemblBacteria; ABP71542; ABP71542; Rsph17025_2655.
DR KEGG; rsq:Rsph17025_2655; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR OMA; TPMMAQY; -.
DR BioCyc; RSPH349102:G1G8M-2735-MON; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..876
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000008084"
FT REGION 829..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 876 AA; 95485 MW; C32E0EB085F39750 CRC64;
MSDDTVTPMM AQYLEIKAQH PGAILFYRMG DFYEMFFEDA ALAAEALDIA LTKRGKHKGE
DIAMCGVPIH AAEGYLLTLI RKGFRVAIAE QMEDPAEAKK RGSKSVVRRE VVRLVTPGTL
TEDSLLEARR HNFLCAFAEI RDEAALAWAD ISTGEFSVTP CPLPRLLPEL ARLAPRELLV
ADERPLDWIE EVGCALTPLA RASFDSASAE KRLCTLFGVG TLDSFGNFTR PELSAMGALV
DYLDLTQRGK LPLLRPPVRE VAGGTVQIDA ATRRNLEITQ ALTGGREGSL LSAVDRTVTA
PGARLLERRL SSPSRDLGLI HDRLAAVSWL TDEPRLREDL RASLRRVPDM DRALSRLALD
RAGPRDMAAI RAGLTQAEAI AGRMPADAPS LLAETLEALR GHENLVDLLD QALVAEPPLL
VRDGGFIAPG FDDDLDETRR LRDEGRGVIA SMQAGFIETT GIQSLKIKHN NVLGYFIEVT
STHAEKMLSP PLSESFIHRQ TTAGQVRFTT VALSELETRI LNAGNRALEL EKMHFAALRT
AILDQAGAIG RAARALAEVD LIAAFADLAV AEDWTEPQVD DSRAFAIEAG RHPVVERALR
RTGTPFVAND CDLSKAETPA VWLITGPNMA GKSTFLRQNA LIALLAQAGS FVPARRAHIG
LVSQIFSRVG ASDDLARGRS TFMVEMVETA AILNQADDRA LVILDEIGRG TATWDGLSIA
WATLEHLHDT NRCRALFATH YHEMTALAGK LTGVENATVS VKEWQGEVIF LHEVRRGAAD
RSYGVQVARL AGLPASVIER ARTVLDALES GERESGPRRQ ALIDDLPLFR AAPPPPAPAA
PPKASQVEER LRAIQPDDLS PREALKLLYD LRALLP