ID   MUTS_CHESB              Reviewed;         881 AA.
AC   Q11B27;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Meso_4031;
OS   Chelativorans sp. (strain BNC1).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Chelativorans; unclassified Chelativorans.
OX   NCBI_TaxID=266779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BNC1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Richardson P.;
RT   "Complete sequence of chromosome of Mesorhizobium sp. BNC1.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000390; ABG65398.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q11B27; -.
DR   SMR; Q11B27; -.
DR   STRING; 266779.Meso_4031; -.
DR   PRIDE; Q11B27; -.
DR   EnsemblBacteria; ABG65398; ABG65398; Meso_4031.
DR   KEGG; mes:Meso_4031; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_5; -.
DR   OMA; TPMMAQY; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..881
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335179"
FT   BINDING         632..639
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   881 AA;  96280 MW;  268B402CC7684D45 CRC64;
     MMQQYIEIKA AHADCLLFYR MGDFYELFFD DAEVASRALG ITLTKRGKHR GEDIPMCGVP
     VHAADDYLQK LIALGHRVAV CEQMEDPAEA KKRGYKAVMR RDVVRLVTPG TITEEKLLDP
     SEANYLMALG RVKGSEELAL AWIDISTGIF RVASTAPDRL LADISRIDPR ELIVAEPVYH
     DAELRPVFDM LGRVVVPQPP VFFDSASAAM RLSRFYGVAT LDGFGRFSRA ELSAIAGAVA
     YVEKTQKAER PPLAAPERDE EGKSLFIDPS TRANLELART LSSSREGSLL KAIDRTVTGA
     GSRLLAERLM SPLTDPQVIA ERLDSVSFFL DEPGLRDRLR AFLKGVPDIS RALSRLALNR
     GGPRDLGALS AGLEAAAAAA DLLRGKEAPS EISAALSTLL SLPAALVSHL DRALADDLPL
     LKRDGGFVRG GYDAELDEMR ALRDQSRRVI AGMERDLIEE TGIRSLKIRH NNILGYYIEV
     RANNAGALNG TDEAKARFIH RQTMANAMRF TTTELADLET RIANAADRAL AIELAVFERL
     VGEVVAASEP LRAAAQALAV LDVSAALACL AEGEDYCRPV VDGSLDFHIE GGRHPVVEQA
     LRKQLGEPFV ANDCDLSPAE GEKAGAIWLL TGPNMGGKST FLRQNALIAV LAQMGSFVPA
     RSARIGVVDR LFSRVGASDD LARGRSTFMV EMVETAAILN QAGERSLVIL DEIGRGTATF
     DGLSIAWAAV EYLHEKNRCR ALFATHFHEM TALTEKLSRL VNVTMRVKEF EGEVIFLHEV
     ARGAADRSYG IQVARLAGLP QTVVERARDV LHRLEEGETG TKAARIVDDL PLFSAAMRQE
     PPKSKAPDHL REELTALNPD DMTPREALEV LYKLKRLVIE G