ID   MUTS_CHLAA              Reviewed;         966 AA.
AC   A9WFZ9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Caur_2954;
OS   Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=324602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29366 / DSM 635 / J-10-fl;
RX   PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA   Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA   Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA   Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT   "Complete genome sequence of the filamentous anoxygenic phototrophic
RT   bacterium Chloroflexus aurantiacus.";
RL   BMC Genomics 12:334-334(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000909; ABY36153.1; -; Genomic_DNA.
DR   RefSeq; WP_012258806.1; NC_010175.1.
DR   RefSeq; YP_001636542.1; NC_010175.1.
DR   AlphaFoldDB; A9WFZ9; -.
DR   SMR; A9WFZ9; -.
DR   STRING; 324602.Caur_2954; -.
DR   EnsemblBacteria; ABY36153; ABY36153; Caur_2954.
DR   KEGG; cau:Caur_2954; -.
DR   PATRIC; fig|324602.8.peg.3352; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_0_0; -.
DR   InParanoid; A9WFZ9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002008; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..966
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335135"
FT   REGION          894..914
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        899..913
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         709..716
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   966 AA;  107716 MW;  101279E191F90F65 CRC64;
     MATIELHAWY RQYRKLKEEA ADAILLFRFG DFYETFDDDA KLIAELLDIT LTRKEYAVDK
     RLPKDQQKLY APMAGMPYHA VDRYVSELIA RGYRVAIAEQ LSETEAMRND TRPRSVYAAG
     LTPVESSGKM VQRAIVRVIT PGTVIDPAML PDRTNNYLAA VIVEQGKVGL AYADLSTGEF
     AAAEFTDARA LMQLQAELAR LSPAEVLVPD DEALRLPNLE PVQARLSQDL APLTKEEREA
     LLPHERVARR LEGASAASWT QGYVTEWPLW RWELATTTEV LCEHLALPSL AVCGLDGRPL
     ATRAAGALLQ YAQVTQRQRV SQLRALRVYH TGAYMLLDPQ TRRNLELLES GGRQGAKASL
     IAVLDRTCTA MGARLLRRWI TQPLIVIEPL QVRQHAVARL VAETMARLEV RSALADLPDM
     ERALNRIAQG ITVATPRDMT QLRAALRKLP AVAQAVQALL PDLLAAEMPG EPPLVFDVCA
     DVLDLLERAL DDDPPALLGS SNYLRAAEEG GERPRRVIRP GFDQRLDALI RASRHAQEFI
     DRLESKERER TGIRSLKVGY NQVFGYYIEI SRAVDAKLIP AHYERKQTLV NAERYVTEEL
     KYYEGLLSDA RLKLVDLERD IFQRLCDELQ PHLDRLRATI AAVARIDALA ALAEVAVRGR
     YVQPRLRTDR VLRIKQGRHP VVERTLSEPF IGNDIDLDGE QAQILIITGP NMAGKSTFLR
     QVALITLMAQ IGSFVPADEA EIGLVDRIFT RIGAQDDIAT GQSTFMVEMT ETAALLMQST
     PRSLIILDEV GRGTSTYDGM AIARAVVEYI HDHPRLGCRT LFATHYHELI ALERELPRVR
     NYHMAAVERD GRVVFLHELR PGGADRSYGI HVAELAGIPP EVIRRASALL ADLEGQRPPS
     SPAQPPAPPA PVVVPAQETG QGMQLSFFDL APHPVVEYLR RLRIEELTPL EALNRLAELQ
     RLAGQG