ID   MUTS_CHLAB              Reviewed;         826 AA.
AC   Q5L554;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CAB798;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CR848038; CAH64240.1; -; Genomic_DNA.
DR   RefSeq; WP_011097337.1; NC_004552.2.
DR   AlphaFoldDB; Q5L554; -.
DR   SMR; Q5L554; -.
DR   EnsemblBacteria; CAH64240; CAH64240; CAB798.
DR   KEGG; cab:CAB798; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..826
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224361"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   826 AA;  92920 MW;  BD59935B9C197C8D CRC64;
     MTSKKTTPMM KQWHQCKEKA GESLLLFRMG DFYEAFYDDA IVLSQNLDIT LTQRQGIPMS
     GIPVSTINGY IDRLVSKGFK VAVAEQLDEA QDNKGKSEPL SRELQRFITP GTLLSSSLLP
     EKANNYIVSI NRVGALFGLA CLDFSTGSFL LQEYDNMKDL VDEICRLAPT EILSCDKFYK
     KHADIIEQIQ QHLKLTLSTY ADWAFEHQFA TQKLSLHFHV SSLDGFGLKG LVPAINSAGA
     LLSYLQDKLL LPVEHISIPK TQGNQKHLLI DTASQVNLEL LTPIHDPQGK SSLLHVMERT
     STPMGGRLLR NTLVNPFYDQ KEILLRQDAV EFLLDRSELR KNLKSLLSQV RDLERLTTKI
     TTSLAGPKDI GMLRDSLNAS IRVCEVLSPL PLPKFFQGRF TLPIGLTSLS ELLSRALLGE
     LPLRISEGNI FCDNHHPDLQ RLRYTKEHSK EWLWQYQETI RQQTGVKKLK VCYSQALGYY
     IEVSSDFAPL LPKEFIRRQS RLHAERFTTE KLQEFQDDML NISDKLQTLE TQLFKDLCAQ
     ILQQREEILS LSQVIADIDY ILSLSDLAAE YNYCRPIVDT SDSLSISGGI HPVAQTLLDK
     GTFIPNDIKM HSTRTRMILI TGPNMAGKST YIRQIALLVI MAQMGSFIPA KSAHIGMIDK
     IFTRIGAGDN LSKGMSTFMV EMAETANILH NATDRSLVIL DEVGRGTSTY DGLAIAQSVV
     EYLLFTEGKK AKTLFATHYK ELTDLENHCP HVENFHASVK ENGGQPVFLY EILKGHSQKS
     FGIHVAKLAG FPLCVISRAQ QILRQLEGPE ATSKQPQEKE LQLTLF