ID   MUTS_CHLCH              Reviewed;         873 AA.
AC   Q3AQZ8;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Cag_1317;
OS   Chlorobium chlorochromatii (strain CaD3).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=340177;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CaD3;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Bryant D., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Chlorobium chlorochromatii CaD3.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000108; ABB28577.1; -; Genomic_DNA.
DR   RefSeq; WP_011362341.1; NC_007514.1.
DR   AlphaFoldDB; Q3AQZ8; -.
DR   SMR; Q3AQZ8; -.
DR   STRING; 340177.Cag_1317; -.
DR   PRIDE; Q3AQZ8; -.
DR   EnsemblBacteria; ABB28577; ABB28577; Cag_1317.
DR   KEGG; cch:Cag_1317; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..873
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224362"
FT   BINDING         628..635
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   873 AA;  97316 MW;  D98E1FBF2FC28D3F CRC64;
     MAKEQSGTKE HSPMMRQYLE VKERYPDYLL LFRVGDFYET FFDDAITVST ALNIVLTKRT
     ADIPMAGFPY HASEGYIAKL IKKGYKVAVC DQVEDPADAK GIVRREITDI VTPGVTYSDK
     LLDDRHNNYL AGVAFLKEGK TLMAGVAFID VTTAEFRITT LLPEELPHFL AGLHPSEILF
     STQEKERTLL LKKSLPSETL ISLLEPWMFS EEQSQTVLLR HFKTHSLKGF GIETAGGNRA
     ALVAAGVILQ YLEETRQNSL SYITRIGELH HTEFMSLDQQ TKRNLEIISS MQDGSLSGSL
     LQVMDRTRNP MGARLLRRWL QRPLKKLTNI QERHNAVEEL VENRTLRESV AEQLAAINDL
     ERSLARIATL RTIPREVRQL GISLAAIPTL QALLSDVTAP RLQALTAALQ PLPKLAEQIE
     SAIDPDAGAT MRDGGYIRAG YNEELDDLRS IASTAKDRLM QIQQEEREAT AISSLKVSYN
     KVFGYYIEIS RANSDKVPAY YEKKQTLVNA ERYTIPALKE YEEKILHAEE KSLLLEAELF
     RNLCQQIATE AATVQANAAL LAELDALCSF AECAVAFDYT KPTMHEGTTL SITAGRHPVL
     ERLLGAEESY IPNDCHFDDK QTMLIITGPN MAGKSSYLRQ IGLIVLLAQA GSFVPAESAS
     LGVVDRIFTR VGASDNLTSG ESTFLVEMNE AANILNNATE RSLLLLDEIG RGTSTFDGMS
     IAWSMCEYIV HTIGAKTLFA THYHELAELE ERLKGVVNYN ATVVETAERV IFLRKIVRGA
     TDNSYGIEVA KMAGMPNDVI SRAREILAGL EKRDVEIPRQ KAPKVNTMQI SLFEETDNQL
     RNAVEAVDVN RLTPLEALLE LQKLQEMARS GGY