ID   MUTS_CHLCV              Reviewed;         826 AA.
AC   Q821V6;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CCA_00829;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE015925; AAP05570.1; -; Genomic_DNA.
DR   RefSeq; WP_011006784.1; NC_003361.3.
DR   AlphaFoldDB; Q821V6; -.
DR   SMR; Q821V6; -.
DR   STRING; 227941.CCA_00829; -.
DR   EnsemblBacteria; AAP05570; AAP05570; CCA_00829.
DR   KEGG; cca:CCA_00829; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_1_3_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..826
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115083"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   826 AA;  92878 MW;  6A0BD2AF43CD2739 CRC64;
     MTSKKPTPMM KQWHQCKEQA GESLLLFRMG DFYEAFYDDA VLLSQNLDIN LTQRQGIPMS
     GIPVSTVNGY IDRLVSKGFK VAIAEQIEEA QNNKGKSEPL ARELQRFVTP GTLLSSSLLP
     EKANNYIVSI YRVGSLFGFS CLDFSTGAFL LNEYDNMKDL IDEICRLAPT EILSCDKFYK
     KHFEIVEQIQ QHLKLTLSTY SDWAFEHQFA TQKLSSHFNV SSLDGFGLKG LVPAINAAGA
     LLSYLQDKLL LPVEHISVPK THGNQKHLLI DTASQVNLEL LTPIHDPQGK SSLLHVMERT
     CTPMGGRLLR NTLVNPFYDQ KEILLRQDAV EFLLNRSELR KNLRSFLSQV RDLERLTTKI
     TTALAGPKDI GMLRDSLNAS MHICEILSPL PLPEFFHGKF TLGLGLASLL ELLSKALFGE
     LPLRISDGNI FSDDHHPDLK RLRYTRENSK EWLWQYQDAI RTQTGVKKLK VCYSQVLGYY
     IEVSSDLAPL LPKDFIRRQS RLHAERFTTE KLQEFQDDML NVSDKLQTLE TQLFKDLCAQ
     ILEQRDAILS LSQVIADTDY ILSLADLAAE YGYCRPIVDT SDSLSITGGM HPVAQTLLDR
     GTFIPNDIKM HSARTRMILI TGPNMAGKST YIRQIALLII MAQMGSFIPA RSAHIGMIDK
     IFTRIGAGDN LSKGMSTFMV EMAETANILH NATDRSLIVL DEVGRGTSTY DGLAIAQSVV
     EYLLFTEGKK AKTLFATHYK ELTDLENHCP HVENFHAGVR ENGGHPVFLY EILKGHSQKS
     FGIHVAKLAG FPLCVISRAQ QILRQLEGPE TTSKQTQEKV QQLTLF