ID   MUTS_CHLFF              Reviewed;         826 AA.
AC   Q255T1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CF0185;
OS   Chlamydia felis (strain Fe/C-56) (Chlamydophila felis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=264202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fe/C-56;
RX   PubMed=16766509; DOI=10.1093/dnares/dsi027;
RA   Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H.,
RA   Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H.,
RA   Hattori M., Kuhara S., Shirai M.;
RT   "Genome sequence of the cat pathogen, Chlamydophila felis.";
RL   DNA Res. 13:15-23(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AP006861; BAE80957.1; -; Genomic_DNA.
DR   RefSeq; WP_011457740.1; NC_007899.1.
DR   AlphaFoldDB; Q255T1; -.
DR   SMR; Q255T1; -.
DR   STRING; 264202.CF0185; -.
DR   KEGG; cfe:CF0185; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001260; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..826
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008052"
FT   BINDING         622..629
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   826 AA;  92987 MW;  1038297E3BF80023 CRC64;
     MTSKKLTPMM KQWHQCKEQA GESLLLFRMG DFYEAFYEDA VLLSQHLDLT LTQRQGIPMS
     GIPVSTINGY IDRLVSKGFK VAVAEQLDEV QDGKGKSEPL SRELQRFITP GTLLSSSLLP
     EKAHNYIVSI NRVGALFGFS CLDFSTGSFL LQEYDNKKDL IDEICRLAPT EILSCDKFYK
     KHSDVIEQLL QHLKLTLSTY SDWAFEHQFA TQKLSAHFKV SSLDGFGLKG LVPAINAAGA
     LLSYLQDKLL LPIEHISIPK THGNQKYLLV DTASQVNLEL LAPLHDPQGK SSLLHVMERT
     CTPMGGRLLR NTLVSPFYDQ KEILLRQDAV EFLLNRSELR KNLRSFLSQV RDLERLTTRV
     TTSLASPKDV GMLRDSLHAS IRVFEVLSPL PLPEFFQGKF IPTIGLASLL DLLSKALLGE
     LPLRISEGNI FSDDYHPDLK RLRYTRENSK EWLWDYQETI RKQTGVKKLK VCYSQALGYY
     IEVSSDLAPL LPKEFIRRQS RLHAERFTTE KLQEFQDDML HVSDKLQMLE TELFKDLCSR
     ILEQREAILS LSQVIADVDY ILSLADLAAE HNYCRPVVDS SDSLAILGGI HPVAQTLLDR
     GTFIPNDIKM HSTRTRMILI TGPNMAGKST YIRQIALLVI MAQMGSFIPA KSAHIGMIDK
     IFTRIGAGDN LSKGMSTFMV EMAETANILH NATDRSLVIL DEVGRGTSTY DGLAIAQSVV
     EYLLFTEGKK AKTLFATHYK ELTDLEKHCP HVENFHAGVK ENGGQPVFLY EILKGHSQRS
     FGIHVAKLAG FPLCVVSRAQ QILRQLEGPE AASRQNQEKV QQLTLF