ID   MUTS_CHLL2              Reviewed;         871 AA.
AC   B3EEE1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Clim_1709;
OS   Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290315;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 245 / NBRC 103803 / 6330;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Zhao F., Li T., Liu Z.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium limicola DSM 245.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001097; ACD90751.1; -; Genomic_DNA.
DR   RefSeq; WP_012466624.1; NC_010803.1.
DR   AlphaFoldDB; B3EEE1; -.
DR   SMR; B3EEE1; -.
DR   STRING; 290315.Clim_1709; -.
DR   PRIDE; B3EEE1; -.
DR   EnsemblBacteria; ACD90751; ACD90751; Clim_1709.
DR   KEGG; cli:Clim_1709; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008841; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000118675"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  96887 MW;  63923E47086511EF CRC64;
     MSAKGVSEKE HSPMMRQYLD VKDRYPDYLL LFRVGDFYET FFDDAREVAA ALNIVLTRRS
     NEIPMAGFPH HASEGYIAKL VKKGYKVAVC DQVEDPAVAK GIVRREITDI ITPGVTYSDS
     ILDDRHNNYL CAIVFLRVGR QTVCGAAFID VTTGEFRIAG LLPEDASVFL RSLHPAELLV
     SAADRERSET LRHALPAGTA FTVLDEWLFR EEQAGEILAR QFRTHSLKGF GIHDNPAGQV
     AAGVILHYLE ETRQSSLQYI TRITPLQSGD YMTLDLQTKR NLEIISSMQD GSINGSLLQV
     IDRTRNPMGA RLLRQWLQRP LLRAADITMR LDAVDELKKM KPFRESVCCD LGQISDLERA
     LARIATLRAI PREVRQLGSA LAVIPLLKQS FQDTVSKRLC SIADALMPLP DLVAMIESAV
     DPEAGASMRD GGYIRKGYHQ ELDDLRQTAS TAKERLLEIQ QEERERTAIG SLKVQFNRVF
     GYYIEISKAN RDKVPPYYEK KQTLVNAERF TIPALKEYEE KILNAEERSL VLEQQLFQAL
     CCRIAGHAEV IQENAALIAE IDCLAAYAVC ADEYGYCKPL IAEHTGLRIL NGRHPVLERI
     LPADEPYIAN DALFDDRQKM LMITGPNMAG KSSYLRQTGL IVLLAQAGCF VPAEQAEIGV
     VDRIFTRVGA SDNLASGEST FLVEMNEAAD ILNNATAKSL LLLDEIGRGT STYDGLAIAW
     SMCEYIHRQI GARTLFATHY HELAELEGLL PGVVNYNASV LESGDRVIFL RKIVRGASDN
     SYGIEVARMS GMPSAVITRA KAILAGMEKR DIATPSSSGL SLQSMQISLF DEIDTRLRTA
     IEVIDIDRMT PLDALVELKK LQGLVRTGNI I