ID   MUTS_CHLMU              Reviewed;         820 AA.
AC   Q9PLD0;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=TC_0174;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE002160; AAF39048.1; -; Genomic_DNA.
DR   PIR; G81733; G81733.
DR   RefSeq; WP_010229708.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PLD0; -.
DR   SMR; Q9PLD0; -.
DR   STRING; 243161.TC_0174; -.
DR   EnsemblBacteria; AAF39048; AAF39048; TC_0174.
DR   GeneID; 1246299; -.
DR   KEGG; cmu:TC_0174; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..820
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115084"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   820 AA;  92174 MW;  7505AC31E66940F9 CRC64;
     MTQKLTPMMQ QWHQCKEQAG DCLLLFRLGE FYEAFFDDAL VLAQNLDITL TQRQNIPMSG
     IPAAYLDGYV DRLVSRGFKI AIAEQADNSE GGKGLVPRTI NRLITPGALL SSSLLPEKAN
     NYIIAISQVG SLYGLSCLDL STGTFLVAEY DNTKDLIEAV YRLAPTELLS HAKFYQKNEP
     VVKQLQQHLR ITLSEHVSWA FEYQSATKKL YTCFQVSSLD GFGLQGLVPA INAAGALLSY
     IQDKLLLPIS HLSIPKIYGQ HKHLLIDKAS QTNLELLSAI HGEHGKGSLL QVMERTSTPM
     GGRLLRNTLV NPFYDLKEIT LRQDSVEFFL KQEPLRKTLK RHLSCVRDLE RLATKISTTL
     ASPKDIGMLR DSLLSCMHIA HDLQSYTLPE FLTNKCLISS SLKSLIEALS TDLLQELPLK
     VSEGNIFADH YHQDLLRLRN IKTNSKSWIL EYQERIRQET GIKKLKVCYA QALGYYIEVA
     SSFAPQLPKE FIRRQSRLHA ERFTTQELQQ FQDEVFSVED KLQTLETKLF KELCCYILQH
     RDLILELSTT IADLDYVISL AELAAEYDYR RPLVDHSDAL SITKGMHPVA LTLLDRGTFI
     PNDTIMHSAQ TRMILLTGPN MAGKSTYIRQ IALLVIMAQM GSFIPARSAH IGIIDKIFTR
     IGAGDNLSKG MSTFMVEMAE TANILHNATD RSLVILDEVG RGTSTYDGLA IAQAVVEFLL
     FTEGKKAKTL FATHYKELTE LELHCQHVEN FHAVVKENGG QPVFMYEIAK GHSKKSFGIH
     VAKLAGFPLS VVSRAQQILH QFEGPDLRPE PEKAQQLVMF