ID   MUTS_CHLP8              Reviewed;         876 AA.
AC   B3QPY5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Cpar_1590;
OS   Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) (Chlorobium vibrioforme
OS   subsp. thiosulfatophilum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX   NCBI_TaxID=517417;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 263 / NCIMB 8327;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Zhao F., Li T., Liu Z., Overmann J.,
RA   Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobaculum parvum NCIB 8327.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001099; ACF11988.1; -; Genomic_DNA.
DR   RefSeq; WP_012502821.1; NC_011027.1.
DR   AlphaFoldDB; B3QPY5; -.
DR   SMR; B3QPY5; -.
DR   STRING; 517417.Cpar_1590; -.
DR   EnsemblBacteria; ACF11988; ACF11988; Cpar_1590.
DR   KEGG; cpc:Cpar_1590; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008811; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..876
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093614"
FT   BINDING         628..635
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   876 AA;  97633 MW;  8597C055F518AAAE CRC64;
     MAKSAQGRKK EPTPMMRQYL EVKERYPEYV LLFRVGDFYE TFLDDAVTVS AALNIVLTKR
     SNGSAGEIPL AGFPHHASEG YIAKLVTKGF KVAVCDQVED PALAKGIVKR EITDIVTPGI
     TYSDKILDDR HNNYLCAVAL FKRGREHLAG VAFVDVTTAE FRMTELPVAE LKDFLQSLHP
     SEILISSRDK ELRDSLAKSM NTLFTVLDEW MFSAEQASQV LENHFKTHSL KGFGIDGVEG
     GRIAAGAILQ YLEEAKQGSL KYLVRIGLVE SAETMTLDIQ TRRNLEIISS MQDGSLNGSL
     LEVIDRTKNP MGARLLRRWL LHPLRKLEAV VQRHDAVEEL LESDSMREES RQLLGGIIDL
     ERALARIATS RAMPREVRLL GSSFALIPQL KAMLASCEAQ RLRHLADRLD SLPELAETIE
     RALDPEASGT LRDGGYIRAG YHEELDELRA ISSGARDRLL EIQQAERSKT SISTLKVQYN
     KVFGYYIEVS RANSDKVPEY YEKKQTLVNA ERYTIPALKE YEEKILTAEE KSQFLEHRLF
     QELCAAVAAE AASIQKTAAA LAELDCLACF ASCADEYRYC RPAMNEGTEL SITGGRHPVL
     ERILGADEPY VANDCRVGSD QQLLIITGPN MAGKSSYLRQ AGLVVLLAQV GSFVPAESAE
     IGLVDRIFTR VGASDNLTSG ESTFLVEMNE AASILNNATE RSLLLLDEIG RGTSTFDGMS
     IAWSMCEFIH DRLRARTLFA THYHELAELE SRFERIVNFN ATVVETADTV IFLRKIVRGA
     SDNSYGIEVA KMAGMPPEVI ERAREILAGM ERREVEVPTQ REAPPRVVSQ QISLFEEEES
     RLRKALSGID INRLTPLDAM MELKRLQDIA LGKSKA