ID   MUTS_CHLPB              Reviewed;         878 AA.
AC   B3EP11;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Cphamn1_0837;
OS   Chlorobium phaeobacteroides (strain BS1).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=331678;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BS1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium phaeobacteroides BS1.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001101; ACE03788.1; -; Genomic_DNA.
DR   RefSeq; WP_012474276.1; NC_010831.1.
DR   AlphaFoldDB; B3EP11; -.
DR   SMR; B3EP11; -.
DR   STRING; 331678.Cphamn1_0837; -.
DR   KEGG; cpb:Cphamn1_0837; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..878
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093615"
FT   BINDING         630..637
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   878 AA;  98302 MW;  DA7F506B88CBE0E7 CRC64;
     MKVTPEKKKG SDTPMMRQYL EVKERYPEYL LLFRVGDFYE SFYEDARKVS EALNIVLTRR
     SNGASADIPM AGFPHHACEG YIARLVKKGF KVTVCDQVED PSQAKGLVRR EITDIVTPGV
     TYSDEILDDK HNNYLCALCF MKKGRERRAG VAFIDVTTAE FRIADLQPEQ VKDMLQSIQP
     SEILLSSRDK SYSDTVSRIL PQEVVVTILD DWMFSEESAS QVIERHFKTH SLKGFGIDSA
     FAARVAAGVV LHYLADTRQN RLQYITRIAL VDARDHMTLD LQTKRNLEII SSMQDGSTSG
     SLLQVIDKTC NPMGARLLRR WLLRPLKRID AIQARLDAVE VLIEEGAVRK ALAEGLGGIH
     DLERALSRIA TFRSMPREVR SLGSSLQKLP AIQALLKDSG SDRLKKLVSG LDLLDEITSI
     IESAIDPEAG AKLRDGGYIR SGYNAELDLL RSVSSNAKSG LMEIQQAERR KTAISTLKIQ
     YNRVFGYYIE VSKANSDKVP DYYEKKQTLV NAERYTIAEL KEYEVKILNA DEKSQMLEQE
     LFRDLCVRIT ACSKEIQQNA EIVAELDCLH SYACCSEAYG YVKPEVKEHG NLSIKNGRHP
     VLERILHVDE PYVPNDCFFD KKQRMLMVTG PNMAGKSSYL RQNGLIVLLA QVGCFVPADA
     AEIGLVDRIF TRVGASDNLT SGESTFLVEM NEAANILNNA TGKSLILLDE IGRGTSTYDG
     MSIAWAMSEY IQSVVGARTL FATHYHELAE LEERFDSISN YNATVVETAD KVVFLRKIVR
     GASDNSYGIE VARMAGMPSE VIQRAKEILS GMEKRDIMIS FGKECAGTIE PQSRQIYLFE
     EEERKLKNAI EALNINTMTP LDALLELKKL QDLAGGDG