ID   MUTS_CHLPD              Reviewed;         872 AA.
AC   A1BHN5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   OrderedLocusNames=Cpha266_1896;
OS   Chlorobium phaeobacteroides (strain DSM 266).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobium/Pelodictyon group; Chlorobium.
OX   NCBI_TaxID=290317;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 266;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Mikhailova N., Li T.,
RA   Overmann J., Bryant D.A., Richardson P.;
RT   "Complete sequence of Chlorobium phaeobacteroides DSM 266.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000492; ABL65912.1; -; Genomic_DNA.
DR   RefSeq; WP_011745719.1; NC_008639.1.
DR   AlphaFoldDB; A1BHN5; -.
DR   SMR; A1BHN5; -.
DR   STRING; 290317.Cpha266_1896; -.
DR   EnsemblBacteria; ABL65912; ABL65912; Cpha266_1896.
DR   KEGG; cph:Cpha266_1896; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008701; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..872
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335134"
FT   BINDING         626..633
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   872 AA;  97614 MW;  CA7417E5E6B1EA6A CRC64;
     MSSPPREHSP MMRQYLDVKE RYPDYLLLFR VGDFYETFFD DAKEVSSALN IVLTRRSNGS
     SSEVPMAGFP HHASEGYIAR LVKKGYKVAV CDQVEDPSEA KGIVRREITD IVTPGITYSD
     KILDDRHNNY LCALALLKEG RRVVAGAAFI DVTTAEFKIA ELLPEEVADF VRSLHPAELL
     IARKEKERFE PVRKEFPPDM VVTELDDWMF GEDQASAVLA RQFKTHSLKG FGIHGNSAGK
     VAAGVILQYL EETRQNRLHY ITRIGTLQNT DYMTLDLQTR RNLEIISSMQ DGTINGSLLQ
     VIDRTANPMG ARLIRRWLQS PLKRLEDIAL RLDAVEEFKD FSPLRREVHG HLSEINDLER
     VLSRIATFRS IPREMRQFGS ALSKIPLLKE ALLQTTTARL QALGRSLVEM PELVALIEKA
     VDPEAGASMR DGGYIRAGYH QELDELRTIA STAKDRLLEI QQEERARTSI SSLKVQFNKV
     FGYYIEISKS NLDKVPDYYE KKQTLVNAER FTIPALKEYE AKILNAEEKS IVLEQRLFHD
     LSLLIAEQAA LVQTNAAVIA EIDCLASFAA VAEEYGYCKP EVAGHDRLLV TGGRHPVLER
     MMSTDDPYVS NDLLFDRKQR LLIITGPNMA GKSSYLRQAG LIVLLAQAGS FVPAQKAEIG
     LVDRIFTRVG ASDNLASGES TFLVEMNEAA SILNNATSKS LLLLDEIGRG TSTSDGMSIA
     WSMSEFIHDS IGARTLFATH YHELAELETR LQGVVNYNAT VIETAEKVIF LRKIVRGASD
     NSYGIEVARM AGMPQEVIVR AKEILAGMEK REIDVSGIKQ PSIESMQISL FEEADSRLRT
     AIENLDLDRL TPLDALIELK KLQDLALKGC GR