ID   MUTS_CHLPN              Reviewed;         828 AA.
AC   Q9Z6W5; Q9JS56;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=CPn_0941, CP_0920, CpB0975;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE001363; AAD19079.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38705.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA99149.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98904.1; -; Genomic_DNA.
DR   PIR; C86608; C86608.
DR   PIR; D81522; D81522.
DR   PIR; G72017; G72017.
DR   RefSeq; NP_225136.1; NC_000922.1.
DR   RefSeq; WP_010892221.1; NZ_LN846995.1.
DR   AlphaFoldDB; Q9Z6W5; -.
DR   SMR; Q9Z6W5; -.
DR   STRING; 115711.CP_0920; -.
DR   EnsemblBacteria; AAD19079; AAD19079; CPn_0941.
DR   EnsemblBacteria; AAF38705; AAF38705; CP_0920.
DR   GeneID; 45050997; -.
DR   KEGG; cpa:CP_0920; -.
DR   KEGG; cpj:mutS; -.
DR   KEGG; cpn:CPn_0941; -.
DR   KEGG; cpt:CpB0975; -.
DR   PATRIC; fig|115713.3.peg.1029; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..828
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115085"
FT   BINDING         624..631
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        579
FT                   /note="R -> H (in Ref. 1; AAD19079)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   828 AA;  93211 MW;  266766382EE0BF6F CRC64;
     MTEKKPTPMM EQWHQCKEKA GDSVLLFRMG DFYEAFYDDA VLLSQHLELT LTQRQGIPMS
     GIPVSTVDTY VDRLIGKGFK VAVAEQFGEP AKEKESKKIG PMARDIQRFV TPGTLLSSTL
     LQEKFNNYIV AINRIGSLFG FACLDLSTGS FFIEECENTK ELVDEICRLA PSEVLSCNKF
     YNKETAIVMQ LQQHLKLTLS TYADWAFEHK FASQKLTTHF QVASLDGFGL KGLVPAINAA
     GGLLSYIQDK LLLPTKHIAI PQTRGKQQKL LIDTASQVNL ELLAPLNDPQ GKNSLLRIMD
     HTSTPMGGRL LRQILISPFY NPKEILVRQD AVEFFLRQVT LRKNIKTYLC QVRDIERLMT
     KVTTGLAGPR DIGTLRDSFS AGAQIYEQLA SATLPEFFID KCSLDTKLAS LIALLSKSLN
     GDLPLRVSDG NIFVDEFHND LKRLRHNQEH SQEWIWEYQE RIRKETGIKK LKICFAQALG
     YYIEVSSEFA PQLPKDFIRR QSRLHAERFT TIELQQFQDD MSNISEKLQT LETQFFKDLC
     SHILQLRTEI LALSQSLADL DYIISLADLA HAQGYCRPRV DMSDTLCIYR GCHPVAKTLV
     DTGKFIPNDT EMRGSQTRMI LLTGPNMAGK STYIRQIALL VIMAQMGSYI PAKSAHIGVI
     DKIFTRIGAG DNLSKGMSTF MVEMAETANI LHNATDRSLV ILDEVGRGTS TYDGLAIAQA
     VVEYLLFTDK KKAKTLFATH YKELTTLEDH CPHVENFHAG VKDKAGQPVF LYEILKGHSQ
     KSFGIHVARL AGFPLCVVSR AQQILRQLEG PESITRPAQD KMQQLTLF