ID   MUTS_CHLT2              Reviewed;         820 AA.
AC   B0B918;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CTL0160;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM884176; CAP03605.1; -; Genomic_DNA.
DR   RefSeq; WP_009873407.1; NC_010287.1.
DR   RefSeq; YP_001654252.1; NC_010287.1.
DR   AlphaFoldDB; B0B918; -.
DR   SMR; B0B918; -.
DR   EnsemblBacteria; CAP03605; CAP03605; CTL0160.
DR   KEGG; ctb:CTL0160; -.
DR   PATRIC; fig|471472.4.peg.174; -.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000795; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..820
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093616"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   820 AA;  92131 MW;  4A68F42138A7DE9C CRC64;
     MTHKLTPMMQ QWHQCKEQAG DCLLLFRLGE FYEAFFDDAL ILAQNLDITL TQRQNVPMSG
     IPATCLDGYV DRLVSRGFKV AIAEQADNTE GSKGLVPRTI NRLITPGALL SSSLLPEKAN
     NYVLAINQVG SLYGLSCLDL SIGTFLVAEY DNTKDLIEAI CRLAPTELLS HAKFYQKNAA
     VIKQLQQHLR ITLSEYVSWA FEYQSATKKL YTCFQVSSLD GFGLQGLVPA INAAGALLSY
     IQDKLLLPIS HLSIPKIYGQ QKHLLIDKAS QTNLELLSPI HGEHGKGSLL QVMERTSTPM
     GGRLLRNTLI NPFYDLKEIT LRQDSVEFFL QQEDLRKILK RQLSCVRDLE RLATKISTSL
     ATPKDIGTLR DSLLSCTHIA DNLQNCALPE FLENKFLIAP PLCSLIKTLS TELIQELPLK
     VSEGNIFANH YHPDLLRLRN IKENSKSWIL EYQERIRNET GIKKLKVCYA QALGYYIEVA
     SNLAPQLPKE FIRRQSRLHA ERFTTQELQQ FQDEVFSVED KLQTLETKLF KELCFYIVEH
     RDLILKLSTA VADLDYVVSL AELAAEYDYR RPLVDHSDAL SITKGMHPVA LTLLDKGTFI
     PNDTVMHSAQ TRMILLTGPN MAGKSTYIRQ IALLVIMAQM GSFIPARSAH IGIVDKIFTR
     IGAGDNLSKG MSTFMVEMAE TANILHNATD RSLVILDEIG RGTSTYDGLA IAQAVVEFLL
     FTDGKKAKTL FATHYKELTE LEMHCQHVEN FHAMVKENSG QPIFMYEIVK GHSKKSFGIH
     VAKLAGFPLS VVSRAQQILH QFEGPDLRPE PEKAQQLVMF