ID   MUTS_CHLTA              Reviewed;         820 AA.
AC   Q3KKQ0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CTA_0862;
OS   Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=315277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-571B / DSM 19440 / HAR-13;
RX   PubMed=16177312; DOI=10.1128/iai.73.10.6407-6418.2005;
RA   Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.;
RT   "Comparative genomic analysis of Chlamydia trachomatis oculotropic and
RT   genitotropic strains.";
RL   Infect. Immun. 73:6407-6418(2005).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000051; AAX51072.1; -; Genomic_DNA.
DR   RefSeq; WP_011324868.1; NC_007429.1.
DR   AlphaFoldDB; Q3KKQ0; -.
DR   SMR; Q3KKQ0; -.
DR   EnsemblBacteria; AAX51072; AAX51072; CTA_0862.
DR   KEGG; cta:CTA_0862; -.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002532; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..820
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000224360"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   820 AA;  92230 MW;  2771048E6D3A85A1 CRC64;
     MTHKLTPMMQ QWHQCKEQAG DCLLLFRLGE FYEAFFDDAL ILAQNLDITL TQRQNVPMSG
     IPATCLDGYV DRLVSRGFKV AIAEQADNTE GSKGLVPRTI NRLITPGALL SSSLLPEKAN
     NYVLAINQVG SLYGLSCLDL SIGTFLVAEY DNTKDLIEAI CRLAPTELLS HAKFYQKNEA
     VIKQLQQHLR ITLSEYVSWA FEYQSATKKL YTCFQVSSLD GFGLQGLVPA INAAGALLSY
     IQDKLLLPIS HLSIPKIYGQ QKHLLIDKAS QTNLELLSPI HGEHRKGSLL QVMERTSTPM
     GGRLLRNTLI NPFYDLKEIT LRQDSVEFFL QQADLRKILK RQLSCVRDLE RLATKISTSL
     ATPKDIGTLR DSLLSCTHIA DNLQNCALPE FLENKFLIAP PLCSLIKTLS TELIQELPLK
     VSEGNIFANH YHPDLLRLRN IKENSKSWIL EYQERIRNET GIKKLKVCYA QALGYYIEVA
     SNLAPQLPKE FIRRQSRLHA ERFTTQELQQ FQDEVFSVED KLQTLETKLF KELCFYIVEH
     RDLILKLSTA VADLDYVVSL AELAAEYDYR RPLVDHSDAL SITKGMHPVA LTLLDKGTFI
     PNDTVMHSAQ TRMILLTGPN MAGKSTYIRQ IALLVIMAQM GSFIPARSAH IGIVDKIFTR
     IGAGDNLSKG MSTFMVEMAE TANILHNATD RSLVILDEIG RGTSTYDGLA IAQAVVEFLL
     FTDGKKAKTL FATHYKELTE LEMHCQHVEN FHAMVKENSG QPIFMYEIVK GHSKKSFGIH
     VAKLAGFPLS VVSRAQQILH QFEGPDLRPE PEKAQQLVMF