ID   MUTS_CHLTE              Reviewed;         878 AA.
AC   Q8KCC0;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; Synonyms=mutS1;
GN   OrderedLocusNames=CT1503;
OS   Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
OS   (Chlorobium tepidum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX   NCBI_TaxID=194439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49652 / DSM 12025 / NBRC 103806 / TLS;
RX   PubMed=12093901; DOI=10.1073/pnas.132181499;
RA   Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J.,
RA   DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D.,
RA   Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M.,
RA   Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V.,
RA   Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M.,
RA   White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A.,
RA   Fraser C.M.;
RT   "The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic,
RT   anaerobic, green-sulfur bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE006470; AAM72730.1; -; Genomic_DNA.
DR   RefSeq; NP_662388.1; NC_002932.3.
DR   RefSeq; WP_010933169.1; NC_002932.3.
DR   AlphaFoldDB; Q8KCC0; -.
DR   SMR; Q8KCC0; -.
DR   STRING; 194439.CT1503; -.
DR   EnsemblBacteria; AAM72730; AAM72730; CT1503.
DR   KEGG; cte:CT1503; -.
DR   PATRIC; fig|194439.7.peg.1363; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_10; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001007; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..878
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115086"
FT   BINDING         630..637
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   878 AA;  97797 MW;  F630307C2D16D942 CRC64;
     MAKSAQGRTK EPTPMMRQYL EVKERYPGYL LLFRVGDFYE TFLDDAVTVS SALNIVLTRR
     SNGGAGEIPL AGFPHHASEG YIAKLVTKGF KVAVCDQVED PALAKGIVKR EITDIVTPGI
     TYSDKILDDR HNNYLCAVAP VKRGREHMAG VAFVDVTTAE FRMTELPLGE LKDFLQSLRP
     SEILISSRDK ELRESLAKSL FSGALFTTLD EWMFTEEQAA RVLENHFKTH SLKGFGIEGY
     EAGRIAAGVI LQYLEEAKQG SLKYLVRIGL VESGETMTLD IQTCRNLEII SSMQDGSLNG
     SLLEVIDRTK NPMGARLLRR WLLHPLRKLE PVVRRHDAVG ELLDAPEMRE GIRGMLGGII
     DLERALARIA TSRAMPREVR QLGSSLAMIP QLKSLLEGSK SLRLRELALR LDPLPELAET
     IEKALDAEAS GTLRDGGYIR AGYHAELDEL RAISSGARDR LLEIQQQERQ RTSISTLKVQ
     YNKVFGYYIE VSRANSDKVP EYYEKKQTLV NAERYTIPAL KEYEEKILTA EEKSQLLEHQ
     LFQELCAMIA EQAASIQTTA AALAELDCLA CFASCADEFG YCRPVMNEGT ELSIRAGRHP
     VLERILGADE PYVANDCQVG SEQQLLIITG PNMAGKSSYL RQVGLVVLLA QVGCFVPAES
     AEIGLVDRIF TRVGASDNLT SGESTFLVEM NEAASILNNA TERSLLLLDE IGRGTSTFDG
     MSIAWSMCEY IHDQLRSRTL FATHYHELAE LESRFERIVN FNATVVETAD TVIFLRKIVR
     GASDNSYGIE VAKMAGMPPE VIERAREILA GMERREVEVP VQRQALPLRV ESRQISLFEE
     EESRLRKALS GIDINRLTPL DALMELKRLQ EIALGKGA