ID   MUTS_CHLTR              Reviewed;         820 AA.
AC   O84797;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=DNA mismatch repair protein MutS;
GN   Name=mutS; OrderedLocusNames=CT_792;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000305}.
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DR   EMBL; AE001273; AAC68387.1; -; Genomic_DNA.
DR   PIR; D71471; D71471.
DR   RefSeq; NP_220311.1; NC_000117.1.
DR   RefSeq; WP_010725347.1; NC_000117.1.
DR   AlphaFoldDB; O84797; -.
DR   SMR; O84797; -.
DR   STRING; 813.O172_04410; -.
DR   EnsemblBacteria; AAC68387; AAC68387; CT_792.
DR   GeneID; 884588; -.
DR   KEGG; ctr:CT_792; -.
DR   PATRIC; fig|272561.5.peg.871; -.
DR   HOGENOM; CLU_002472_4_0_0; -.
DR   InParanoid; O84797; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR   GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..820
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115087"
FT   BINDING         618..625
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   820 AA;  92131 MW;  A5EF7B2B6D3A85A5 CRC64;
     MTHKLTPMMQ QWHQCKEQAG DCLLLFRLGE FYEAFFDDAL ILAQNLDITL TQRQNVPMSG
     IPATCLDGYV DRLVSRGFKV AIAEQADNTE GSKGLVPRTI NRLITPGALL SSSLLPEKAN
     NYVLAINQVG SLYGLSCLDL SIGTFLVAEY DNTKDLIEAI CRLAPTELLS HAKFYQKNEA
     VIKQLQQHLR ITLSEYVSWA FEYQSATKKL YTCFQVSSLD GFGLQGLVPA INAAGALLSY
     IQDKLLLPIS HLSIPKIYGQ QKHLLIDKAS QTNLELLSPI HGEHGKGSLL QVMERTSTPM
     GGRLLRNTLI NPFYDLKEIT LRQDSVEFFL QQADLRKILK RQLSCVRDLE RLATKISTSL
     ATPKDIGTLR DSLLSCTHIA DNLQNCALPE FLENKFLIAP PLCSLIKTLS TELIQELPLK
     VSEGNIFANH YHPDLLRLRN IKENSKSWIL EYQERIRNET GIKKLKVCYA QALGYYIEVA
     SNLAPQLPKE FIRRQSRLHA ERFTTQELQQ FQDEVFSVED KLQTLETKLF KELCFYIVEH
     RDLILKLSTA VADLDYVVSL AELAAEYDYR RPLVDHSDAL SITKGMHPVA LTLLDKGTFI
     PNDTVMHSAQ TRMILLTGPN MAGKSTYIRQ IALLVIMAQM GSFIPARSAH IGIVDKIFTR
     IGAGDNLSKG MSTFMVEMAE TANILHNATD RSLVILDEIG RGTSTYDGLA IAQAVVEFLL
     FTDGKKAKTL FATHYKELTE LEMHCQHVEN FHAMVKENSG QPIFMYEIVK GHSKKSFGIH
     VAKLAGFPLS VVSRAQQILH QFEGPDLRPE PEKAQQLVMF