ID   MUTS_CHRSD              Reviewed;         859 AA.
AC   Q1QZX5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Csal_0621;
OS   Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 /
OS   NCIMB 13768 / 1H11).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Chromohalobacter.
OX   NCBI_TaxID=290398;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11;
RX   PubMed=22675587; DOI=10.4056/sigs.2285059;
RA   Copeland A., O'Connor K., Lucas S., Lapidus A., Berry K.W., Detter J.C.,
RA   Del Rio T.G., Hammon N., Dalin E., Tice H., Pitluck S., Bruce D.,
RA   Goodwin L., Han C., Tapia R., Saunders E., Schmutz J., Brettin T.,
RA   Larimer F., Land M., Hauser L., Vargas C., Nieto J.J., Kyrpides N.C.,
RA   Ivanova N., Goker M., Klenk H.P., Csonka L.N., Woyke T.;
RT   "Complete genome sequence of the halophilic and highly halotolerant
RT   Chromohalobacter salexigens type strain (1H11(T)).";
RL   Stand. Genomic Sci. 5:379-388(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000285; ABE57983.1; -; Genomic_DNA.
DR   RefSeq; WP_011505929.1; NC_007963.1.
DR   AlphaFoldDB; Q1QZX5; -.
DR   SMR; Q1QZX5; -.
DR   STRING; 290398.Csal_0621; -.
DR   EnsemblBacteria; ABE57983; ABE57983; Csal_0621.
DR   KEGG; csa:Csal_0621; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_6; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000239; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..859
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335136"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   859 AA;  94483 MW;  9EBD20AB760DB02A CRC64;
     MSQASAQHTP MMAQYLKIKR EHPEVLLFYR MGDFYELFYD DAKRAASLLD ITLTQRGQSA
     GQPIPMAGVP YHSAESYLAR LVKSGESVAI CEQIGDPATA KGPVERKVVR IVTPGTLHDE
     ALLDARRDNL VLAVHPQGDR WGLAWLELSS GHFSVLEVDG ESDLLSEIQR LDPAELLAAE
     SLSLPPALAE RPGFRRQSDW LFDLESATRL LCDQFGVADL RGFGCAHLTT ALTAAGVLID
     YARDTQRSRL PHVTGIAVET RDEAVVIDAA SRRNLEIDTN LGGGFDNTLA SVLDTTATAM
     GSRQLKRWLN RPLRDIAQIQ SRQAAVQCLI DADRHATLRD ALKAIGDIER ILARVALYSA
     RPRDLARLRD ALNALPALEH DLAELDEGTA IDALKHHIRP YPELAETLSR ALVDNPPVVI
     RDGGVIGTGF DAELDEYRGL AEHAGDYLVE LETRERERTG LVGLKVGYNR VHGYYIEIPR
     AQAREAPAEY IRRQTLKNAE RFIIPELKEF EDKALSAKSR ALAREKLLYD GLLETLNVDL
     QALQGTARAL ATLDVLACFA ERALALDFVR PRLSDQPGLR IRGGRHPVVE HVSDHPFVPN
     DLMLDETRRL LVITGPNMGG KSTYMRQAAL IALLAHTGSC VPADEAEIGP VDRIFTRIGS
     SDDLAGGRST FMVEMTETAT ILHNATEHSL VLMDEIGRGT STFDGLSLAW ASAEHLVERR
     AFTLFATHYF EMTALTEPYD SVANVHLTAA EHRDGIVFMH RVEEGPASQS YGLQVAQLAG
     VPPRVVARAR EKLATLEQQE VHQAGTRGGL GDSDAAAPQQ ADLFASAPHP VVEALEKLDL
     DAISPRQAMA LLYEWREQC