ID   MUTS_CITBB              Reviewed;         837 AA.
AC   B5EA63;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Gbem_1753;
OS   Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 /
OS   Bem) (Geobacter bemidjiensis).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Citrifermentans.
OX   NCBI_TaxID=404380;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Lykidis A., Lovley D., Richardson P.;
RT   "Complete sequence of Geobacter bemidjiensis BEM.";
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001124; ACH38769.1; -; Genomic_DNA.
DR   RefSeq; WP_012530187.1; NC_011146.1.
DR   AlphaFoldDB; B5EA63; -.
DR   SMR; B5EA63; -.
DR   STRING; 404380.Gbem_1753; -.
DR   EnsemblBacteria; ACH38769; ACH38769; Gbem_1753.
DR   KEGG; gbm:Gbem_1753; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_7; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008825; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..837
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093629"
FT   BINDING         621..628
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   837 AA;  92596 MW;  62ECD548A52D95DF CRC64;
     MSEMTPMMRQ FLEIKAEHPD AILFFRCGDF YEMFLDDAVK ASRILGITLT SRNKNADGSE
     VPLCGVPYHS CAPYIAKLVE AGEKVAICEQ AEDPKQAKGI VKREVVKVIT PGLVIEDASL
     SPKENNYLLA LCCDGECYGL SYLDLSTGEF RVTELDGLQA ALAELTCIGP REIILPVSFR
     EEPKRKEVAH VIVDRSITYF EEWVYDPDYC KRLVANQFKG ATAESLGCDR LPIALLAAGA
     VLHYLVDTQK GHAPHVTGIT PYNENEHLLL DESTRRNLEL TATLSEGKRK GSLLGLMDRT
     VTAMGGRKLK QWINYPLMDL KKIWLRQDAI QELMEAPGTR EAMKSLLAGV YDLERLNGRI
     SLASASAKDL SALRSSLSRL PAIKEQVAAC GAGLLKELNA GIDPLDELCD LISRAIVDDP
     PFVLRDGGII ADGYNQELDE LRAISREGKG FIARLEAQEK GRTGISSLKI RYNKVFGYYI
     EVTKANVSAI PDDYIRRQTL ANAERYITPE LKEYEEKVLG AEDRIKDLEF SLFQEVREAA
     AAQGERIART ADRLACLDVL ASLSELAHDK GYCRPEVHEG SELSITEGRH PVIDDMHSSE
     RFVPNDTLLD NGENQLIIIT GPNMAGKSTF MRQVALISLM AQMGSFVPAD KALIPLVDRI
     FTRVGASDNL ARGTSTFDGV SIAWAVAEFL HDNKMHAAKT LFATHYHELT ELAVTRPGIK
     NFNIAVREWN ERIIFLRKIV PGGASHSYGI QVARLAGLPQ AVIERAKEIL VNLEKGEYGE
     GGVPRLARGK KVPPPSPQLS LFGAGDDQIR ERLKEVEVAL LTPLEALNLV DELKRMI