ID   MUTS_CLOAB              Reviewed;         869 AA.
AC   Q97I19;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CA_C1837;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AE001437; AAK79801.1; -; Genomic_DNA.
DR   PIR; F97126; F97126.
DR   RefSeq; NP_348461.1; NC_003030.1.
DR   RefSeq; WP_010965142.1; NC_003030.1.
DR   AlphaFoldDB; Q97I19; -.
DR   SMR; Q97I19; -.
DR   STRING; 272562.CA_C1837; -.
DR   EnsemblBacteria; AAK79801; AAK79801; CA_C1837.
DR   KEGG; cac:CA_C1837; -.
DR   PATRIC; fig|272562.8.peg.2042; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..869
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000115089"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   869 AA;  99175 MW;  C6E792AF6D4E60B0 CRC64;
     MSISPMMQQY LSIKENHKDC ILFFRVGDFY EMFFEDAEVA SRELELVLTG KDCGLEKRAP
     MCGVPHHAYA IYASKLVSKG YKVAVAEQLE DPSLAKGIVK RDVIKVLTPG TYTDSSFLED
     TKNNYIMSLF IHDKVSAMCF ADISTGEFNL TETELDFEII LNEISKFSPK ELVLQENLDD
     KLVDKIRERF DVVYNRFSNE YFKEHRNENL KAQFSNYAEV NMTEGLKSCA NGLIKYIIDT
     QKTALTHIDE LQKYEIVDFL SIDINSRRNL ELTETLKDKS KKGSLLWVLD KTSTAMGGRQ
     IRKWIERPLI DDEKINLRLD AVEEMLTNVS YNEDLKELLK QVYDIERLAG KISSKSVNAK
     EMISLRGSIE KLPAIKKLIK NFNSELLVNM ENALDDLGDI YKLLYESIND NPSLSIKEGN
     IIKEGYNKDI DELRLAKSHG KQWIASLENT EREVTGIKSL KVSYNKVFGY YIEITKSNLN
     LVPEGRYIRK QTLTNSERYI TPELKEMEEK ILGAEEKLVL LEYNVFCEIR ERIEKEIDRI
     KGSAKILSEL DCICSFADVA RENNYCKPVI KRDGTLVIKE GRHPVVEKVI ASGNFVANDT
     VINNSDNVMM LITGPNMAGK STYMRQVGLI VLMAQIGCFV PASAAEISIC DKIFTRIGAS
     DDLNAGKSTF MVEMWEVSHI LKNATKNSLI LLDEVGRGTS TYDGLSIAWS VIEYICKSEN
     LKCKTLFATH YHELTKLEGE IEGLKNYSIA VKKVNDDIIF LRKIISKGAD ESYGIEVAKI
     AGLPEEVLVR AREILKDLEE AKPKTAENTE DKKTNIVKEE PKKDSYQIDF NYLERESILK
     ELKDTEIMDM NPIECMNKLY EFIKRAKKL