ID   MUTS_CLOB1              Reviewed;         932 AA.
AC   A7FUL0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CLB_1735;
OS   Clostridium botulinum (strain ATCC 19397 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441770;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19397 / Type A;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000726; ABS32425.1; -; Genomic_DNA.
DR   RefSeq; WP_012047675.1; NC_009697.1.
DR   AlphaFoldDB; A7FUL0; -.
DR   SMR; A7FUL0; -.
DR   GeneID; 5186055; -.
DR   KEGG; cba:CLB_1735; -.
DR   HOGENOM; CLU_002472_3_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..932
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335138"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   932 AA;  106364 MW;  579C85DD4A0AD4A9 CRC64;
     MGLTPMMRQY LEVKESCKDC ILFFRLGDFY EMFFEDAKVA SKELELVLTG RDCGLEERAP
     MCGIPYHAAN TYIGRLVSAG YKIAICEQLE DPSASKGIVK RGIIKIITPG TYTDSSFLEE
     NKNNYIMSFY LDDNMCAMSF ADISTGEFNS THSNFKEAVV LDEISKFAPR EIVLEENIKE
     SFIHTIKERF PNISISKIKQ ENFDYNIDNN LKEQFNNFNE NEYETIVKKS ANGLLYYIFH
     TQKNILSNIN KIDYYSIVDY LTIDVNSRRN LEITENLREK TKKGSLLWAL DKTNTAMGGR
     QLRRWIEQPL INKNPIENRL NAVEELLNNI SLQEDLKEDL KSIYDIERIV GKVASKSVNA
     KELISLKCSI GKVPYIKEYL SNFKSDLFLN MEQCIDTLED IHKLLDKALL DNPSLSVKEG
     NIIKEGFNEE VDSLREAKSN GKKWIASLEQ KEKEETGIKS LKVSYNKVFG YFIEITKANL
     NLVPEGRYIR KQTLSNAERY ITPELKEMEE KILGAEEKLI DIEYKLFTEI RDFIEENIDR
     MQKTARIISD IDCLCSLATV ALENNYIKPN INAKDEILIE EGRHPVVEKV IPKGEFISND
     SLIDTKENQL ILITGPNMAG KSTYMRQVAL ITIMAQIGSF VPAKKANISI CDKIFTRIGA
     SDDLAAGKST FMVEMWEVSN ILKNATSKSL VLLDEVGRGT STYDGLSIAW SVIEYICNNK
     NLRCKTLFAT HYHELTKLED NIEGVKNYSV SVSELENEIV FLRKIIKGGA DQSYGIEVAK
     LAGLPSPVIN RAKEILQHIE GDKEENSLNI APSKEYKSKD YIEVSKDTSN TKNNLGSEIK
     HDTLSETNTD TIIEDESTKE HLSSNKKQIN CRINDEKSIK KEVAVDSFQI NFEYIKRDKI
     IEEIKNIDIL NMTPMEGFNK LYDIINKTKD ID