ID   MUTS_CLOB6              Reviewed;         932 AA.
AC   C3KX35;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2009, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CLJ_B1978;
OS   Clostridium botulinum (strain 657 / Type Ba4).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=515621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=657 / Type Ba4;
RA   Shrivastava S., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Genome sequence of Clostridium botulinum Ba4 strain 657.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001083; ACQ54103.1; -; Genomic_DNA.
DR   RefSeq; WP_003362818.1; NC_012658.1.
DR   AlphaFoldDB; C3KX35; -.
DR   SMR; C3KX35; -.
DR   EnsemblBacteria; ACQ54103; ACQ54103; CLJ_B1978.
DR   KEGG; cbi:CLJ_B1978; -.
DR   HOGENOM; CLU_002472_1_3_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002333; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..932
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000202732"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   932 AA;  106273 MW;  C414346EB6F64796 CRC64;
     MGLTPMMKQY LEVKESCKDC ILFFRLGDFY EMFFEDAKVA SKELELVLTG RDCGLEERAP
     MCGIPYHAAN TYIGRLVSAG YKIAICEQLE DPSASKGIVK RGIIKIITPG TYTDSSFLEE
     NKNNYIMSLY LDDNMCAMSF ADISTGEFNS THSNFKEAVV LDEISKFAPR EIVLEENIKE
     SFIHTIKERF PNISISKIKE ENFAYNIDNN LKEQFNNFNE NEYETIVKKS ANGLLYYIFH
     TQKNILSNIN KIDYYSIVDY LTIDVNSRRN LEITENLREK TKKGSLLWVL DKTNTAMGGR
     QLRRWIEQPL INKNPIENRL NAVEELLNNI SLQEDLKEDL KSIYDIERIV GKVASKSVNA
     KELISLKCSI GKVPYIKKYL SSFKSDLFLN MEKCIDTLED IHKLLDKALL DNPSLSVKEG
     NIIKEGFNEE VDSLREAKSN GKKWIASLEQ KEKEETGIKS LKVSYNKVFG YFIEITKANL
     NLVPEGRYIR KQTLSNAERY ITPELKEMEE KILGAEEKLI DIEYKLFTKI RDFIEENIDR
     MQKTARIISD IDCLCSLATV ALENNYIKPN INAKDEILIE EGRHPVVEKV IPKGEFISND
     SLIDTKENQL ILITGPNMAG KSTYMRQVAL ITIMAQIGSF VPAKKANISI CDKIFTRIGA
     SDDLAAGKST FMVEMWEVSN ILKNATSKSL VLLDEVGRGT STYDGLSIAW SVIEYICNNK
     NLRCKTLFAT HYHELTKLED NIEGVKNYSV SVSELENEIV FLRKIIRGGA DQSYGIEVAK
     LAGLPSPVIN RAKEILQHIE GDKEENSLNI TPSKEYKSKD YIEVSKDTLN TKNNLESEIK
     HDTLSETNTA TIIEDESTKE HLSSNKKQIN CKRNGEKSIK KEVAVDSFQI NFEHIKKDKI
     IEEIKNIDIL NMTPMEGFNK LYDIINKTKD ID