ID   MUTS_CLOB8              Reviewed;         928 AA.
AC   A6LWJ5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=Cbei_2569;
OS   Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium
OS   acetobutylicum).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=290402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51743 / NCIMB 8052;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G.,
RA   Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W.,
RA   Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B.,
RA   Blaschek H., Richardson P.;
RT   "Complete sequence of Clostridium beijerinckii NCIMB 8052.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000721; ABR34725.1; -; Genomic_DNA.
DR   RefSeq; WP_012058780.1; NC_009617.1.
DR   AlphaFoldDB; A6LWJ5; -.
DR   SMR; A6LWJ5; -.
DR   STRING; 290402.Cbei_2569; -.
DR   EnsemblBacteria; ABR34725; ABR34725; Cbei_2569.
DR   KEGG; cbe:Cbei_2569; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000000565; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..928
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335137"
FT   REGION          854..880
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   928 AA;  104513 MW;  FD2730574B1485B1 CRC64;
     MALTPMMVEY MKTKEEYSDC ILFYRLGDFY EMFFDDAITV SRELELVLTG KNCGLEERAP
     MCGIPHHAAA AYIPRLVNKG YKVAICEQLE DPKEAKGIVK RGVVKIITPG TFIDANSSLE
     NDNTYLMTIY ESDERIGLAV SDISTGEFKT TSFDNIKITL LDEISKVAPK EILVDKNISQ
     SLIDDIKGIT TALITEKDFN EFIVSKEEII DQFSDLEVSG LVNEREISSR VLLKYIYETQ
     KMSLTNINLL EQYEIINYMT IDGNSRRNLE LTESIREKSK KGSLLWVLDK SATSMGGRTI
     RKWIEEPLII KSEIEKRLSG VSEAFSSISF NEDLRSSLKD IYDIERIVGK ISNKNVNAKD
     MLSLKASLDK LPSIKELLGT ANSELLKEYY ENLDELSDIR ELLESSIKEE PSLSIKEGNI
     IKDGYNSEVD ELRQSKLHGK EWIAALENRE REFTGIKSLK VGYNKVFGYY IEISKSNYNS
     IPEGRYVRKQ TLANAERYIT EELKIMEDKI LGAEEKLINL EYSLFTDIRD SIEKEIARLK
     KSARIISNLD GISTLALIAL ENDYVKPEIN EDGIIEIVDG RHPVVEKVIG RGEFVSNNTT
     LNQSDKELLL ITGPNMAGKS TYMRQVALIT LMAQIGSFVP ASSANISICD KIFTRIGASD
     DLAGGKSTFM VEMWEVSNIL KNATSKSLVL LDEVGRGTST YDGLSIAWSV IEYITGNENL
     RCKTLFATHY HELVKLEGVL PGVKNYSVAV KKMKDSVIFL RKIVEGGADE SYGIEVAKLA
     GLPDDVINRA KEILLGLEGE NNFDIHKVTN TEIIENEVAV DINQANNVVT ITEKACESKS
     EYIEKVEAKD SFDKAKSNKD DHRIDEKTEN SSKKHKNKDS SNNMQLDFTF IEKEAFLKEV
     SEVDILSLNP MEAMNTLYRL VAEAKKLK