ID   MUTS_CLOBA              Reviewed;         941 AA.
AC   B2V1M2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CLH_1684;
OS   Clostridium botulinum (strain Alaska E43 / Type E3).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=508767;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Alaska E43 / Type E3;
RA   Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Complete genome sequence of Clostridium botulinum E3 str. Alaska E43.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001078; ACD53561.1; -; Genomic_DNA.
DR   RefSeq; WP_012451434.1; NC_010723.1.
DR   AlphaFoldDB; B2V1M2; -.
DR   SMR; B2V1M2; -.
DR   KEGG; cbt:CLH_1684; -.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..941
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093618"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   941 AA;  106538 MW;  636A73DA1DEAE8EE CRC64;
     MALTPMMVEY MKTKEEYNDC ILFYRLGDFY EMFFDDALTV SRELELVLTG KNCGLEERAP
     MCGIPHHAAA AYIPRLVTKG YKVAICEQLE DPKQSKGIVK RGVVKVITPG TFIDSNSNLE
     NDNTYLMVIS EHEDKFGIAM SDISTGEFKT TSFNNIKMSL LDEISKVSPK EILVDNNISE
     DLLEEINNVL PVLITKKDFN EFLVSKEELI EQFSDLEVSG LTIEREIPSK VLLKYINETQ
     KMSLTNINLL EQYEIINYMT IDGNSRRNLE LTESIREKTK KGSLLWVLDK SATSMGGRTL
     RKWIDEPLIV KDEIEKRLSG VEEVFNSIGF NEDLRSALKE IYDIERIVGK ISNKNVNAKD
     LLSLKSSLDK LPCIKKLLKD TSSELLKGYY ENLDELIDVR DLLNDSIKED PGLGLKEGNI
     IKDGYNNLVD ELRQSKLHGK EWIAALENRE REFTGIKSLK VGYNKVFGYY IEISKSNYNS
     IPEGRYIRKQ TLANAERFIT EELKVMEDKI LGSEEKLINL EYSIFVEIRD KIEKEISRLK
     KSARIISDLD GISTLALVAL ENDYIKPEIN TNGLIKITDG RHPVVEKVIG KGDFVSNNTA
     LNQTDKELLL ITGPNMAGKS TYMRQVALIT LMAQMGSFVP ATSANISICD KIFTRIGASD
     DLAGGKSTFM VEMWEVSNIL KNATSNSLVL LDEVGRGTST YDGLSIAWSV IEYITKNKNL
     RCKTLFATHY HELVKLEGIL PGVKNYSVAV KKLKDSVVFL RKIVEGGADE SYGIEVAKLA
     GLPENVINRA REILEDLESK NTFDINKLSS CSMVSNNTKE IAADSIKNEE DKVISNAQNI
     DVNETNCNYN EEKILKIETQ NSEYEETIKF LKSEIKELQE SNKKHNKKHK DASNDNMQIN
     FEVMEKENFI KEISDVDILN LNPMEAMNTL YKVVTDAKKL Q