ID   MUTS_CLOBB              Reviewed;         942 AA.
AC   B2TIC3;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CLL_A1823;
OS   Clostridium botulinum (strain Eklund 17B / Type B).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=935198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Eklund 17B / Type B;
RA   Brinkac L.M., Brown J.L., Bruce D., Detter C., Munk C., Smith L.A.,
RA   Smith T.J., Sutton G., Brettin T.S.;
RT   "Complete sequence of Clostridium botulinum strain Eklund.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP001056; ACD24612.1; -; Genomic_DNA.
DR   RefSeq; WP_012425353.1; NC_018648.1.
DR   AlphaFoldDB; B2TIC3; -.
DR   SMR; B2TIC3; -.
DR   EnsemblBacteria; ACD24612; ACD24612; CLL_A1823.
DR   KEGG; cbk:CLL_A1823; -.
DR   PATRIC; fig|935198.13.peg.1769; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000001195; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..942
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000093619"
FT   BINDING         613..620
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   942 AA;  106493 MW;  90ADDCC198FF711E CRC64;
     MALTPMMVEY MKTKEEYNDC ILFYRLGDFY EMFFDDALTV SRELELVLTG KNCGLEERAP
     MCGIPHHAAA AYIPRLVTKG YKVAICEQLE DPKQSKGIVK RGVVKVITPG TFIDSNSNLE
     NDNTYLMVIS EYEDKFGIAM SDISTGEFKT TSFNNIKMSL LDEISKVSPK EILVDININE
     ELLTEINNVL PVLITKKDFN EFLVSKEELI EQFSDLEVSG LTIEREIPSK VLLKYINETQ
     KMSLTNINLL EQYEIINYMT IDGNSRRNLE LTESIREKTK KGSLLWVIDK SATSMGGRTL
     RKWIDEPLIV KDEIEKRLSG VEEVFNSIGF NEDLRSALKE IYDIERIVGK ISNKNVNAKD
     LLSLKSSLDK LPCIKELLKN TSSELLKGYY ENLDELIDVR DLLNDSIKED PGLGLKEGNI
     IKDGYNNLVD ELRESKLHGK EWIAALENRE REFTGIKSLK VGYNKVFGYY IEISKSNYNS
     IPEGRYIRKQ TLANAERFIT EELKVMEDKI LGSEEKLINL EYSIFVEIRD KIEEEISRLK
     KSARIISDLD GISTLALVAL ENDYIKPEIN TDGLIKIIDG RHPVVEKVIG KGDFVSNNTA
     LNQTDKELLL ITGPNMAGKS TYMRQVALIT LMAQMGSFVP ATSANISICD KIFTRIGASD
     DLAGGKSTFM VEMWEVSNIL KNATSNSLVL LDEVGRGTST YDGLSIAWSV IEYITKNKDL
     RCKTLFATHY HELVKLEGIL PGVKNYSVAV KKLKDSVVFL RKIVEGGADE SYGIEVAKLA
     GLPENVINRA REILEDLEGK NTFDINKVSS CSMVSNNIKE IAVDSTKNSE DKVISNAQNI
     DVNETSCKDT TKEKILRVET QNAEYEEAIK SLKSEITKLQ ELNKKHNKKH KDVSNDNMQI
     NFEVMEKENF IKELSEVDIL GLNPMEAMNT LYRLVTDAKK LQ