MUTS_CLOBH
ID MUTS_CLOBH Reviewed; 932 AA.
AC A5I2S2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=CBO1800, CLC_1742;
OS Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=441771;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX PubMed=17519437; DOI=10.1101/gr.6282807;
RA Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA White B., Whithead S., Parkhill J.;
RT "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT Hall A and comparative analysis of the clostridial genomes.";
RL Genome Res. 17:1082-1092(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT plasmids.";
RL PLoS ONE 2:E1271-E1271(2007).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CP000727; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM412317; CAL83339.1; -; Genomic_DNA.
DR EMBL; CP000727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; YP_001254300.1; NC_009495.1.
DR AlphaFoldDB; A5I2S2; -.
DR SMR; A5I2S2; -.
DR KEGG; cbo:CBO1800; -.
DR PATRIC; fig|413999.7.peg.1771; -.
DR HOGENOM; CLU_002472_3_0_9; -.
DR OMA; TPMMAQY; -.
DR Proteomes; UP000001986; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.110; -; 1.
DR Gene3D; 3.40.1170.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; PTHR11361; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; SSF48334; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53150; SSF53150; 1.
DR SUPFAM; SSF55271; SSF55271; 1.
DR TIGRFAMs; TIGR01070; mutS1; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..932
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000093620"
FT BINDING 615..622
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 932 AA; 106364 MW; 579C85DD4A0AD4A9 CRC64;
MGLTPMMRQY LEVKESCKDC ILFFRLGDFY EMFFEDAKVA SKELELVLTG RDCGLEERAP
MCGIPYHAAN TYIGRLVSAG YKIAICEQLE DPSASKGIVK RGIIKIITPG TYTDSSFLEE
NKNNYIMSFY LDDNMCAMSF ADISTGEFNS THSNFKEAVV LDEISKFAPR EIVLEENIKE
SFIHTIKERF PNISISKIKQ ENFDYNIDNN LKEQFNNFNE NEYETIVKKS ANGLLYYIFH
TQKNILSNIN KIDYYSIVDY LTIDVNSRRN LEITENLREK TKKGSLLWAL DKTNTAMGGR
QLRRWIEQPL INKNPIENRL NAVEELLNNI SLQEDLKEDL KSIYDIERIV GKVASKSVNA
KELISLKCSI GKVPYIKEYL SNFKSDLFLN MEQCIDTLED IHKLLDKALL DNPSLSVKEG
NIIKEGFNEE VDSLREAKSN GKKWIASLEQ KEKEETGIKS LKVSYNKVFG YFIEITKANL
NLVPEGRYIR KQTLSNAERY ITPELKEMEE KILGAEEKLI DIEYKLFTEI RDFIEENIDR
MQKTARIISD IDCLCSLATV ALENNYIKPN INAKDEILIE EGRHPVVEKV IPKGEFISND
SLIDTKENQL ILITGPNMAG KSTYMRQVAL ITIMAQIGSF VPAKKANISI CDKIFTRIGA
SDDLAAGKST FMVEMWEVSN ILKNATSKSL VLLDEVGRGT STYDGLSIAW SVIEYICNNK
NLRCKTLFAT HYHELTKLED NIEGVKNYSV SVSELENEIV FLRKIIKGGA DQSYGIEVAK
LAGLPSPVIN RAKEILQHIE GDKEENSLNI APSKEYKSKD YIEVSKDTSN TKNNLGSEIK
HDTLSETNTD TIIEDESTKE HLSSNKKQIN CRINDEKSIK KEVAVDSFQI NFEYIKRDKI
IEEIKNIDIL NMTPMEGFNK LYDIINKTKD ID
