ID   MUTS_CLOBL              Reviewed;         932 AA.
AC   A7GE45;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CLI_1795;
OS   Clostridium botulinum (strain Langeland / NCTC 10281 / Type F).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Langeland / NCTC 10281 / Type F;
RA   Brinkac L.M., Daugherty S., Dodson R.J., Madupu R., Brown J.L., Bruce D.,
RA   Detter C., Munk C., Smith L.A., Smith T.J., White O., Brettin T.S.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000728; ABS41447.1; -; Genomic_DNA.
DR   RefSeq; WP_012099793.1; NC_009699.1.
DR   AlphaFoldDB; A7GE45; -.
DR   SMR; A7GE45; -.
DR   EnsemblBacteria; ABS41447; ABS41447; CLI_1795.
DR   KEGG; cbf:CLI_1795; -.
DR   HOGENOM; CLU_002472_3_0_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000002410; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..932
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335139"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   932 AA;  106276 MW;  4E1B99591D4FF018 CRC64;
     MGLTPMMRQY LEVKESCKDC ILFFRLGDFY EMFFEDAKVA SKELELVLTG RDCGLEERAP
     MCGIPYHAAN TYVGRLVSAG YKIAICEQLE DPSASKGIVK RGIIKIITPG TYTDSSFLEE
     NKNNYIMSFY LDDNMCAMSF ADISTGEFNS THSNFKEAVV LDEISKFAPR EIVLEENIKE
     SFIHTIKERF PNISISKIKE ENFDYNIDNN LKEQFNNFNE NEYETIVKKS ANGLLYYIFH
     TQKNILSNIN KIDYYSIVDY LTIDVNSRRN LEITENLREK TKKGSLLWVL DKTNTAMGGR
     QLRRWIEQPL INKNPIENRL NAVEELLNNI SLQEDLKEDL KSIYDIERIV GKVASKSVNA
     KELISLKCSI GKVPYIKKYL SGFKSDLFLN MEQCIDTLED IHKLLDKALL DNPSLSVKEG
     NIIKEGFNEE VDSLREAKSN GKKWIASLEQ KEKEETGIKS LKVSYNKVFG YFIEITKANL
     NLVPEGRYIR KQTLSNAERY ITPELKEMEE KILGAEEKLI DIEYKLFTEI RDFIEENIDR
     MQKTARIISD IDCLCSLATV ALENNYIKPN INAKDEILIE EGRHPVVEKV IPKGEFISND
     SLIDTKENQL ILITGPNMAG KSTYMRQVAL ITIMAQIGSF VPAKKANISI CDKIFTRIGA
     SDDLAAGKST FMVEMWEVSN ILKNATSKSL VLLDEVGRGT STYDGLSIAW SVIEYICNNK
     NLRCKTLFAT HYHELTKLED NIEGVKNYSV SVSELENEIV FLRKIIRGGA DQSYGIEVAK
     LAGLPSPVIN RAKEILQHIE GDKEENSLNI APSKEYKSKD YIEVSKDTLN TKNNLGSEIK
     HDTLSETNTA TIIEDESTKE HLSSNKKQIN CRTNDEKSIK KEVAVDSFQI NFEYIKIDKI
     IEEIKNIDIL NMTPMEGFNK LYDIINKTKD ID