ID   MUTS_CLOBM              Reviewed;         932 AA.
AC   B1KSA3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CLK_1181;
OS   Clostridium botulinum (strain Loch Maree / Type A3).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=498214;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Loch Maree / Type A3;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000962; ACA54382.1; -; Genomic_DNA.
DR   RefSeq; WP_012342496.1; NC_010520.1.
DR   AlphaFoldDB; B1KSA3; -.
DR   SMR; B1KSA3; -.
DR   EnsemblBacteria; ACA54382; ACA54382; CLK_1181.
DR   KEGG; cbl:CLK_1181; -.
DR   HOGENOM; CLU_002472_3_1_9; -.
DR   OMA; TPMMAQY; -.
DR   Proteomes; UP000000722; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..932
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335140"
FT   BINDING         615..622
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   932 AA;  106467 MW;  6D204FFFC2953CE3 CRC64;
     MGLTPMMRQY LEVKESCKDC ILFFRLGDFY EMFFEDAKVA SKELELVLTG RDCGLEERAP
     MCGIPYHAAN TYIGRLVSAG YKIAICEQLE DPSASKGIVK RGIIKIITPG TYTDSSFLEE
     NKNNYIMSFY LDDNMCSMSF ADISTGEFNS THSNFKEAVV LDEISKFAPR EIVLEENIKE
     SFIHTIKERF PNISISKIKE ENFDYNIDNN LREQFNNFSE NEYETIVKKS ANGLLYYIFH
     TQKNILSNIN KIDYYSIVDY LTIDVNSRRN LEITENLREK IKKGSLLWVL DKTNTAMGGR
     QLRRWIEQPL INKTPIENRL NAVEELLNNI SLQEDLKEDL KSIYDIERIV GKVASKSVNA
     KELISLKCSI GKVPYIKKYL SSFKSDLFLN MEQCIDTLED IHKLLDKALL DNPSLSVKEG
     NIIKEGFNEE VDSLREAKSN GKKWIASLEQ KEKEETGIKS LKVSYNKVFG YFIEITKANL
     NLVPEGRYIR KQTLSNAERY ITPELKEMEE KILGAEEKLI DIEYKLFTEI RDFIEENIDR
     MQKTARIISD IDCLCSLATV ALENNYIKPN INAKDEILIE EGRHPVVEKV IPKGEFISND
     SLIDTKENQL ILITGPNMAG KSTYMRQVAL ITIMAQIGSF VPAKEANISI CDKIFTRIGA
     SDDLAAGKST FMVEMWEVSN ILKNATSKSL VLLDEVGRGT STYDGLSIAW SVIEYICNNK
     NLRCKTLFAT HYHELTKLED NIKGVKNYSV SVSELENEIV FLRKIIRGGA DQSYGIEVAK
     LAGLPSPVIN RAKEILQHIE GDKEENSLNI TPSKEYKSKD YIEVSKDTLN TKNNLESEIK
     HDTLSETNTA TIIEDESIKE HLCSNKKQIQ CKKNNEKSIK KELAVDSFQI NFEHIKKDKV
     IEEIKNIDIL NMTPMEGFNK LYDIINKTKD ID