ID   MUTS_CLOD6              Reviewed;         947 AA.
AC   Q187T6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CD630_19770;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; AM180355; CAJ68852.2; -; Genomic_DNA.
DR   RefSeq; WP_003435264.1; NZ_CP010905.2.
DR   RefSeq; YP_001088483.2; NC_009089.1.
DR   AlphaFoldDB; Q187T6; -.
DR   SMR; Q187T6; -.
DR   STRING; 272563.CD630_19770; -.
DR   PRIDE; Q187T6; -.
DR   EnsemblBacteria; CAJ68852; CAJ68852; CD630_19770.
DR   KEGG; cdf:CD630_19770; -.
DR   KEGG; pdc:CDIF630_02182; -.
DR   PATRIC; fig|272563.120.peg.2074; -.
DR   eggNOG; COG0249; Bacteria.
DR   OMA; TPMMAQY; -.
DR   PhylomeDB; Q187T6; -.
DR   BioCyc; PDIF272563:G12WB-2119-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..947
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_0000335142"
FT   BINDING         620..627
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   947 AA;  108579 MW;  1C7D9F7394D55628 CRC64;
     MQIDMNKLTP MMKQYLEVKN RYKDCILFFR LGDFYEMFFE DALVASKALE IALTGKACGL
     EERAPMCGVP FHSANSYISK LVENGYKVAI GEQMEDPSTA KGIVRREVIR VITPGTVLDG
     NLLENKKNNY LLSLYKDGTN IGLTYVDIST GETNATCLNE DKVIEEIAKI HPTEIIINDL
     DFIEKLRDIA TVSNIYINES FSDNYLDINI LKEYFPDVYL QKLKFDDKGL IKSSLSILLN
     YIYNTQKQIT SNINNINIYN SSEYMVLDMF TRTNLELTQT IRGNKKKGSL LHVLDKTSTA
     MGGRLLRKYV EEPLINKSKI ENRLDVIEEI KDDFILREDL NDILKNIYDI ERICGKIAFE
     RVTPKELIHL KNSIEKLPNL KDTINLSNAK ILKEYVSEMD KLDDIYNLID EAILEEPTIT
     IKDGNIIKSD FSDELKELRE ISKNGAFLVK EIENREREKT GVKSLKIGFN KVFGYYIEIT
     KANFKQAKLD ETYIRKQTLS NAERYITPEL KEIEEKILHA EEKIKSLEYE IFVEIRDTIY
     KNIDRIQKVA KTIANIDVFV SLATVAHINN YVKPAINENN KLDIRNGRHP VVENIVGEEN
     FVPNDTYLNR GENIINIITG PNMSGKSTYM RQTAIIALMA HIGSFVPAES ADIPILDRIF
     TRVGASDDLS QGQSTFMVEM NEVSLILKNA TERSLVILDE IGRGTSTYDG ISLAWSIVEY
     IQKNIRCKTL FATHYHELTD LEEEFKEVKN YSIAVKEDGE GIIFLRKIIP QGADKSYGIY
     VAKLAKLPDE VIERAKYILK DLEKNHVYNS VAINGDKENN NIINSNLDEE LVKVNQSNFK
     NKYESLKIEH ELIVKDYKHI KKDYDKLNSK FKALNDEVAL MKQNDDKEKI NQEDSVKEVA
     LTQISFDSVN RDILSEEILN LDILNMTPLD AINSLYNLQR KAKEIKS