ID   MUTS_CLOK5              Reviewed;         871 AA.
AC   A5N8I5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=CKL_1574;
OS   Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=431943;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8527 / DSM 555 / NCIMB 10680;
RX   PubMed=18218779; DOI=10.1073/pnas.0711093105;
RA   Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H.,
RA   Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F.,
RA   Hagemeier C., Thauer R.K., Gottschalk G.;
RT   "The genome of Clostridium kluyveri, a strict anaerobe with unique
RT   metabolic features.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000673; EDK33616.1; -; Genomic_DNA.
DR   RefSeq; WP_012101969.1; NC_009706.1.
DR   AlphaFoldDB; A5N8I5; -.
DR   SMR; A5N8I5; -.
DR   STRING; 431943.CKL_1574; -.
DR   EnsemblBacteria; EDK33616; EDK33616; CKL_1574.
DR   KEGG; ckl:CKL_1574; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000002411; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..871
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000075553"
FT   REGION          801..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         616..623
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   871 AA;  99500 MW;  F5E419A08D8DC773 CRC64;
     MGLTPMMRQY MEIKENYKDC ILFFRLGDFY EMFFDDAKIA AAELELVLTA RECGLKEKAP
     MCGIPYHAAK SYIGRMVNKG YKIAICEQLE DPAQSKGIVK RGIIKVITPG TYMDSYFLDE
     NENNYIMCLY INNNEGSNCA LCFADISTGE FNCTDTPFNL SVILDEICKF NPREIIIQED
     IDSNILQGIV EVFNETFSRV DECYFQKGEE VLREQFKDLN LREYTPEIIK CGGALVKYIK
     HTQKTNLSHI NKFQYYNIVD YLTIDINSKR NLEIVESLRE SKKKGSLLGV IDKTNTSMGG
     RQLRKWIEQP LIDRNKIMER LDSVEEILNN ICYHEDLKEA LKNIYDIERL AGKISSKSVN
     AKELNSLKSS IEKIPDIKVI LSNFETSLLK NMYKNLDELK DIYMLLDKAI LDNPSVSLKE
     GNLIKEGYDS EIDRLKEAKV KGKDWIASLE SSERELTKIK SLKIGYNKVF GYYIEVTKSN
     LNLVPEHRYI RKQTLSNAER YITPELKEME DKILGAEEKL IYLEYNAFVE VRDKVEKEVT
     RIQNSARIIS EVDCLTSLAR AALENNYCKP EITLSDRVYI EEGRHPVVEN MLSTGEFVSN
     DTDIDTGENQ LLLITGPNMA GKSTYMRQVA LVTIMAQIGS FVPAKSASIS ICDKIFTRIG
     ASDDLASGKS TFMVEMWEVS NILKNATNKS LILLDEVGRG TSTYDGLSIA WSVIEYICRE
     SKLRCKTLFA THYHELTKLE GKIKGVKNYC VSVKEVENNI VFLRKIIRGG ADQSYGIEVA
     KLAGLPEEVL KRAREILNSL ETEKTEESME GTNLPKKKKE EKTSSQGEQL KFLDIEKENL
     INEIRDIDIL NMTPMEGFNK LYDIIKKVKS I