ID   MUTS_CLONN              Reviewed;         909 AA.
AC   A0Q0M6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN   Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=NT01CX_2105;
OS   Clostridium novyi (strain NT).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=386415;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NT;
RX   PubMed=17115055; DOI=10.1038/nbt1256;
RA   Bettegowda C., Huang X., Lin J., Cheong I., Kohli M., Szabo S.A., Zhang X.,
RA   Diaz L.A. Jr., Velculescu V.E., Parmigiani G., Kinzler K.W., Vogelstein B.,
RA   Zhou S.;
RT   "The genome and transcriptomes of the anti-tumor agent Clostridium novyi-
RT   NT.";
RL   Nat. Biotechnol. 24:1573-1580(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is possible that it carries out the mismatch recognition step. This
CC       protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR   EMBL; CP000382; ABK60996.1; -; Genomic_DNA.
DR   RefSeq; WP_011722178.1; NC_008593.1.
DR   AlphaFoldDB; A0Q0M6; -.
DR   SMR; A0Q0M6; -.
DR   STRING; 386415.NT01CX_2105; -.
DR   EnsemblBacteria; ABK60996; ABK60996; NT01CX_2105.
DR   KEGG; cno:NT01CX_2105; -.
DR   PATRIC; fig|386415.7.peg.1210; -.
DR   eggNOG; COG0249; Bacteria.
DR   HOGENOM; CLU_002472_4_0_9; -.
DR   OMA; TPMMAQY; -.
DR   OrthoDB; 15991at2; -.
DR   Proteomes; UP000008220; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.110; -; 1.
DR   Gene3D; 3.40.1170.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00096; MutS; 1.
DR   InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR   InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR   InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR   InterPro; IPR036678; MutS_con_dom_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; PTHR11361; 1.
DR   Pfam; PF01624; MutS_I; 1.
DR   Pfam; PF05188; MutS_II; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF05190; MutS_IV; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; SSF48334; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53150; SSF53150; 1.
DR   SUPFAM; SSF55271; SSF55271; 1.
DR   TIGRFAMs; TIGR01070; mutS1; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..909
FT                   /note="DNA mismatch repair protein MutS"
FT                   /id="PRO_1000008053"
FT   REGION          798..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        798..813
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         614..621
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ   SEQUENCE   909 AA;  103344 MW;  52266B3F369C5A04 CRC64;
     MALTPMMKQY LEVKERNKDC ILFFRLGDFY EMFFEDAETA ARELELVLTG RDCGLENRAP
     MCGIPYHAAN TYISRLITKG YKVAICEQLE DPSKAKGIVK RDVIKIYTPG TYSDASFLEE
     TKNNYLMSLY LENELVCMAF ADVSTGDFQC TYVKYNESSI LDEISKFMPK EIVIIDSIDD
     TIIKAIKERF EVSFTVKNKD FFYLNASLNL KNQFPDFKEE NYDDIVITGC NGLLNYIIET
     QKTTLIHINK LDYYETVDYL SIDINSRRNL ELTETLRDKS KKGSLLWVLD KTTTAMGARL
     LRKWVEQPLI HKEIIENRQN AVEEILNNVP LLDDLRNNLK DVYDIERLAG KISSKTVNAK
     ELLSLKNSIG NLPIIKKIIE NYNTDLLKNI YSSLDCLEDL YSLLDNSILP SPALSIKEGG
     IIKDGYNKTI DELRMAKSHG TEWIASLEEQ ERNITGIKSL KVKYNKVFGY YIEITKSNLN
     QVPENRYIRK QTLANCERFI TPELKEVEDK ILGAQEKLME LEYNVFVEIR ELIEKEIYRI
     KNTAKLISSI DVLQSLAIVA LESNYSKPII KLDGELLIKD GRHPVVEKMI PRDSFVSNDT
     ILDNKDHQLL LITGPNMAGK STYMRQVALI TLMAQIGSFV PAKEAEIVIC DKIFTRIGAS
     DDLARGKSTF MVEMWEVANI LNNATNKSLI LLDEVGRGTS TYDGLSIAWA VIEYICKDNN
     LKSKTLFATH YHELTSLEGK IKGVKNYSIA VKKVDDDIIF LRKIIEGGAD ESYGIEVAKL
     AGIPSVVTNR AKEILNTLEE NSPQNNDISK ESSSSSNSHD KLESSVIKES ESNIKTYDEI
     SNLETNKIKE AQVEVAVEKE VTQDIKQIGF LDIEKEALIK EISSIDILNM TVKDCFDKLY
     DIINKAKSL